Dysphagia Clinical Trial
Official title:
Randomized Controled Clinical Study to Evaluate the Efficacy of the Increase of the Sensorial Stimuli as a Therapeutic Strategy for the Treatment of Elderly Patients With Oropharyngeal Dysphagia.
This study will evaluate with videofluoroscopy (radiologic method to study the deglutitive
physiology) the effect on the deglutition of two therapeutic treatments with the duration of
2 weeks, based on the increase of the sensorial stimuli in older patients with oropharyngeal
dysphagia:
1. Stimulation of Transient Receptor Potential Vanilloid 1 (TRPV1) oropharynx chanels
using a natural agonist administrated in the alimentary bolus.
2. Stimulation of the sensorial neurons of the pharynx and larynx using transcutaneous
electrical stimuli.
Moreover, with an electroencephalographic study we will assess the effect of both treatments
in the cortical neuroplasticity.
This study will evaluate with videofluoroscopy (radiologic method to study the deglutitive
physiology) the effect on the deglutition of two therapeutic treatments with the duration of
2 weeks, based on the increase of the sensorial stimuli in older patients with oropharyngeal
dysphagia:
1. Stimulation of Transient Receptor Potential Vanilloid 1 (TRPV1) oropharynx chanels
using a natural agonist administrated in the alimentary bolus.
2. Stimulation of the sensorial neurons of the pharynx and larynx using transcutaneous
electrical stimuli.
The study will last 5 weeks per patient. At the beginning of the study, patients will
receive a videofluoroscopic evaluation and an electroencephalography (evoked potentials) to
asses dysphagia and cortical activity of deglutition. After that the first day of the third
week they will begin the treatment (group a or b) during 2 weeks. Finally in the fifth week
an evaluation of dysphagia will be performed the same way as in week 1 to asses the effects
of the treatments.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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