Dyslipidemias Clinical Trial
Official title:
Genetical Characterization of Patients Presenting With Dyslipidemia
The mechanism of the majority of the dyslipidemia is multifactorial at the molecular level
and remains elusive in more than 50% of the patients in many clinical conditions. Next
generation sequencing, a booming strategy, improves the molecular diagnosis efficiency in
both monogenic and polygenic dyslipidemia.
In order to decipher the mechanisms involved in the occurrence of dyslipidemia, in addition
to the exploration of known candidate genes and Single Nucleotide Polymorphisms (SNP)
involved in polygenic modulation, new genes involved in the regulation of lipoprotein
metabolism or associated with lipids concentrations need to be sequenced in large groups of
dyslipidemic patients.
The goal of this project is to gain new insight into genotype/phenotype correlation.
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