Dyslipidemias Clinical Trial
Official title:
Effects of Exercise on Fructose-induced Postprandial Lipemia
Verified date | May 2017 |
Source | Federal University of Rio Grande do Sul |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Cardiovascular Diseases (CVDs) are the leading causes of death in the world and in Brazil.
In 2001, 12.45 million deaths on the globe (21% of the total) were caused by some CVD.
The composition of modern man's diet has changed drastically with the industrialization of
food, resulting in the transition from a diet rich in fibers and complex carbohydrates to
one with a high content of sugars and fats. Since the current dietary pattern is
characterized by the consumption of three or more meals a day, containing a quantity of fat
in the range of 20 to 70 g, individuals spend a large part of the day in the postprandial
state, with continuous fluctuation of lipemia Over 18 hours. Food intake (postprandial
state) is the dynamic, unstable response of the body that refers to rapid hormonal and
lipoprotein remodeling. It is well established in the literature that high-fat meals (lipid
overload) cause an increase in plasma triglycerides. Hypertriglyceridemia and / or elevated
triglyceride-rich lipoproteins (LRT) (chylomicrons, VLDL and their remnants) in the
postprandial state induces endothelial dysfunction via increased oxidative stress and is an
independent risk factor for CVDs. Therefore, Postprandial Lipemia (PPL) is counted as an
early marker of atherosclerotic process, metabolic abnormalities and endothelial
dysfunction.
High-carbohydrate (CHO) diets may promote increased LDL-c, TG, VLDL and HDL-c reduction, as
well as PPL, generating a lipid profile associated with an increased risk of CVDs. This
effect appears to be more pronounced with the inclusion of simple carbohydrates (mono and
disaccharides), although it also occurs with diets rich in complex carbohydrates
(polysaccharides).
High fructose diets (HFDs) are a known model of induction of insulin resistance,
dyslipidemia and DM2 in primates and humans. The chronic effect of fructose consumption has
been well studied in the last decades due to its connection with obesity, resistance to
Insulin, accumulation of visceral fat and dyslipidemia.
As the consumption of fructose is progressively increasing in society and its chronic
exposure can generate a phenotypic effect of dyslipidemia and, consequently, the increased
risk of CVDs, prevention and treatment strategies should be seen as an important public
health issue . Thus, the objective of this study is to understand the effects of exercise on
fat metabolism, since there is a lack of robust evidence about the possible cardioprotective
and hypolipemic role of the same on HFD.
Status | Completed |
Enrollment | 12 |
Est. completion date | December 15, 2016 |
Est. primary completion date | December 15, 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 20 Years to 40 Years |
Eligibility |
Inclusion Criteria: - BMI (18,5 to 24,9 kg/m²) - Sedentary lifestyle (< 150 minutes exercise per week) - Fructose intake < 25g per day - Otherwise healthy Exclusion Criteria: - Smoker - Drug user - Using some medicine - Fat metabolism disorders - Orthopedic disorders |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Federal University of Rio Grande do Sul |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Triglycerides | Parameter was analyzed by Cobas C111 | 4 hour postprandial test | |
Primary | VLDL | Parameter was analyzed by ELISA | 4 hour postprandial test | |
Secondary | Glycemia | Parameter was analyzed by Cobas C111 | 4 hour postprandial test | |
Secondary | Insulin | Parameter was analyzed by Cobas C111 | 4 hour postprandial test | |
Secondary | HDL | Parameter was analyzed by Cobas C111 | 4 hour postprandial test | |
Secondary | Non-HDL cholesterol | Parameter was analyzed by formula | 4 hour postprandial test |
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