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Saturated Fatty Acids and HDL Metabolism

Dyslipidemia Clinical Trial

Official title:
Effects of C16:0 Versus C18:0 on HDL Metabolism and Other Cardiometabolic Risk Markers: A Dietary Intervention Study in Healthy Normal-weight and Overweight Subjects

Clinical Trial Summary

The purpose of this study is to determine whether palmitic acid (C16:0) and stearic acid (C18:0) have different effects on HDL metabolism during the fasted state.

Clinical Trial Description

Study design:

Double blind, randomized, cross-over study with two different diets: one diet will be high in palmitic acid (C16:0) and the other diet will be high in stearic acid (C18:0). Subjects will receive both diets for 4 weeks with a wash-out period of 4-6 weeks in between. Contrast in the intakes of palmitic acid and stearic acid is 6% of energy. A postprandial test will be carried out at the end of each dietary period.

Study population:

Accounting for a dropout rate of 20%, 40 healthy men and postmenopausal women, aged between 45 and 70 year, having a BMI (body mass index) between ≥ 18.0 and ≤ 30.0 kg/m2 will be recruited. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02835651
Study type Interventional
Source Maastricht University Medical Center
Contact
Status Completed
Phase N/A
Start date April 14, 2016
Completion date July 1, 2017
View Details
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