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Clinical Trial Summary

According to the 2016 International Children's Continence Society standardization of terminology of lower urinary tract function in children, dysfunctional voiding (DV) is a "urodynamic entity characterized by an intermittent and/or fluctuating uroflow rate due to involuntary intermittent contractions of the striated muscle of the external urethral sphincter or pelvic floor during voiding in neurologically normal individuals" . Symptoms vary from mild daytime frequency and urgency to daytime and nighttime wetting, pelvic holding maneuvers, voiding difficulties, urinary tract infections and vesicoureteral reflux (VUR). There are several ways of treating DV, including urotherapy, pharmacotherapy, surgery in the most severe cases, and even Botulinum toxin type A application in certain children. ''Urotherapy'' stands for non-surgical, non-pharmacologic treatment of lower urinary tract function and can be defined as a bladder re-education or rehabilitation program aiming at correction of filling and voiding difficulties. It involves the change of habits that a child has acquired during the period of toilet training and the development of motor control of the micturition reflex. Urotherapy starts with both parental and child education about the importance of regular hydratation and voiding, constipation treatment and genital hygiene. Together with this standard treatment, the pelvic floor muscle (PFM) retraining is initiated, and it includes pelvic floor exercises and various forms of biofeedback (visual, tactile, auditory, electromyography) with the same aim in mind - to help the child establish pelvic floor awareness and control, and relearn pelvic floor muscle relaxation. During the past decade, it has been shown that the PFMs are not an isolated unit, but a part of the abdominal capsule, which they form together with the diaphragm, superficial and deep abdominal muscles. As lower abdominal and PFM act synergistically, it is important that both be relaxed during voiding. Diaphragmatic breathing exercises are easy to learn and serve to teach the children abdominal relaxation.


Clinical Trial Description

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Study Design


Related Conditions & MeSH terms


NCT number NCT04981340
Study type Interventional
Source University of Nis
Contact Vesna D Zivkovic, MD
Phone +381648839124
Email petvesna67@gmail.com
Status Not yet recruiting
Phase N/A
Start date September 18, 2021
Completion date October 30, 2022

See also
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Recruiting NCT06165731 - At-Home Diaphragmatic Interventions for Voiding Abnormalities (DIVA) N/A
Completed NCT06040333 - Dynamic Neuromuscular Stabilization Training in Dysfunctional Voiding N/A
Not yet recruiting NCT04147793 - Case Control Study to Investigate the Use of Urethral Pressure Profile Measurement in Children
Completed NCT05313984 - OptiLUTS Part C: The Development of a Symptom Assessment Tool in Sacral Neuromodulation.
Active, not recruiting NCT04490642 - Linguistic Validation of the Childhood Bladder and Bowel Dysfunction Questionnaire (CBBDQ) for 5-12 Years Old in Korean
Terminated NCT01465581 - Treatment of Neurogenic Incontinence by Surgery to Cut the Filum Terminale N/A
Completed NCT02806713 - The Effect of Oral PhenazopyrIdine on Perioperative Voiding After Mid-urethral sliNg (EPIPhANy Study) Phase 3