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Dwarfism, Pituitary clinical trials

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NCT ID: NCT01365351 Completed - Clinical trials for Growth Hormone Deficiency

Online Surveillance of Treatment of Children With Growth Hormone Deficiency With ZOMACTON

Start date: December 1, 2007
Phase: N/A
Study type: Observational

The purpose of this study is to investigate long-term treatment with Zomacton® for pituitary short stature in children with insufficient growth hormone production and/or short stature caused by Turner syndrome.

NCT ID: NCT01359488 Completed - Clinical trials for Growth Hormone Deficiency

VRS-317 in Adult Subjects With Growth Hormone Deficiency

Start date: March 2011
Phase: Phase 1
Study type: Interventional

The purpose of this research study is to determine the safety and tolerability of up to five doses of VRS-317 in Adult Growth Hormone Deficient patients. - Patients will be evaluated for evidence of activity of VRS-317 by measurement of changes from baseline in insulin-like growth factor-1 (IGF-I) and binding protein (IGFBP-3), and bone turnover (bone alkaline phosphatase) - Descriptive pharmacokinetic (PK) and pharmacodynamic (PD) parameters (IGF-I and IGFBP-3) will be determined by standard model independent methods based on the plasma concentration-time data of each subject. These parameters include: Cmax, Tmax, AUCavg, AUC0-inf, and t1/2. - The purpose is to determine the appropriate dose of VRS-317 to maintain a normal range (for appropriate age/gender) for IGF-I levels in adult patients for up to one month after administration of a single dose

NCT ID: NCT01351818 Completed - Clinical trials for Growth Hormone Deficiency

Adipocyte Function and Somtropin Deficiency

FAYDS
Start date: May 2005
Phase: N/A
Study type: Observational

To assess the influence of exogenous GH (growth hormone) administration on adipocyte endocrine function (leptin, adiponectin, and resistin) and on ghrelin secretion in children with delayed growth due to GH deficiency. Study hypothesis: hormones produced by the adipocyte (leptin, adiponectin, and resistin) and ghrelin may exert a certain control on production of GH and IGF-I, and GH may in turn have a regulatory effect on such hormones.

NCT ID: NCT01342146 Completed - Clinical trials for Growth Hormone Deficiency

Efficiency and Safety Study of Pegylated Somatropin to Treat Growth Hormone Deficiency Children

PD
Start date: May 2006
Phase: Phase 2
Study type: Interventional

The purpose of the multicenter, randomized, open-label, controlled phase II study is to determine whether pegylated recombinant human growth hormone is effective in the treatment of children with growth hormone deficiency.

NCT ID: NCT01327924 Completed - Clinical trials for Chronic Kidney Disease

Usability and Tolerability of the Norditropin NordiFlex® Injection Device in Children Never Previously Treated With Growth Hormone

Start date: April 2011
Phase: N/A
Study type: Observational

This study is conducted in Europe. The purpose of this study is to assess the impact on daily life for children new to using a growth hormone injection device.

NCT ID: NCT01282164 Completed - Clinical trials for Adult Growth Hormone Deficiency

The Glucagon Stimulation Test for Evaluation of Adult Growth Hormone Deficiency and Adrenocorticotropic Axis

GST
Start date: January 2011
Phase: N/A
Study type: Interventional

The purpose of this study is to find out if the Glucagon Stimulation Test (GST) is a reliable alternative to the Insulin Tolerance Test (ITT) for diagnosis of Growth Hormone Deficiency (GHD) and adrenal insufficiency. In some patients the accuracy of the GST for evaluation of adrenal insufficiency is compared to the adrenocorticotropin hormone (ACTH ) stimulation test.

NCT ID: NCT01247675 Completed - Clinical trials for Growth Hormone Deficient Adults

A Safety, Pharmacokinetic and Pharmacodynamic Study of ACP-001 (TransCon PEG hGH) in Adults With Growth Hormone Deficiency

Start date: November 2010
Phase: Phase 2
Study type: Interventional

This study investigates the pharmacokinetic profile (PK) and pharmacodynamic response (PD) of three different doses of ACP-001 given once-a-week compared to one dose-level of an approved daily human growth hormone product over a period of 4 weeks (4 weekly administrations versus 28 daily administrations).

NCT ID: NCT01245374 Completed - Clinical trials for Chronic Kidney Disease

Norditropin NordiFlex® Device Compared to the Device Previously Used by Patients or Parents

Start date: November 2010
Phase: Phase 4
Study type: Interventional

This study is conducted in Europe. The aim of this study is to compare the easiness of use of Norditropin NordiFlex® device to the device previously used by patients or parents.

NCT ID: NCT01187550 Completed - Dwarfism, Pituitary Clinical Trials

Predictive Markers in Chinese Growth Hormone Deficiency (GHD) Children Treated With Saizen®

Start date: March 2007
Phase: Phase 4
Study type: Interventional

This is an open-label, prospective, multicentric, non-comparative, non-randomized Phase IV interventional study in which subjects pre-diagnosed with Growth Hormone Deficiency (GHD) were treated for 4 weeks with Saizen to compare the response between GHD children born appropriate for gestational age (AGA) and those born small for gestation age (SGA) after 4 weeks of Saizen therapy.

NCT ID: NCT01157793 Completed - Clinical trials for Growth Hormone Deficiency

A Multicentre, Randomised, Open-label, Controlled Study to Evaluate the Effects of Saizen® on Cardiac Function in Growth Hormone Deficient(GHD) Subjects During the Transition Phase From Childhood to Adulthood

Start date: September 2003
Phase: Phase 4
Study type: Interventional

This was a 48-week, open-label, prospective, multicentric, randomised, comparative with parallel control, Phase 4 study to evaluate the effects of Saizen on cardiac function in GHD subjects during the transition phase from childhood to adulthood. The study was designed to evaluate whether recombinant-human growth hormone (r-hGH) treatment also benefits young subjects with GHD. Some trials have already been published on this subject, but they were mainly focused on the bone density.