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Clinical Trial Summary

The purpose of this study is to assess the efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) of satralizumab, a humanized anti-interleukin-6 receptor (aIL-6R) monoclonal antibody, in ambulatory and non-ambulatory patients with Duchenne muscular dystrophy (DMD) age ≥ 8 to < 16 years old receiving corticosteroid therapy.


Clinical Trial Description

Participants will be included in two groups: those presenting with fractures at baseline and those that are fracture naive at baseline. The study will assess the potential of satralizumab to improve bone fragility and to increase muscle function. A weight tier based dose of satralizumab will be given by subcutaneous injection every 4 weeks ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06450639
Study type Interventional
Source Hoffmann-La Roche
Contact Reference Study ID Number: BN45398 https://forpatients.roche.com
Phone 888-662-6728 (U.S.)
Email global-roche-genentech-trials@gene.com
Status Not yet recruiting
Phase Phase 2
Start date September 30, 2024
Completion date June 30, 2027

See also
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