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Quantitative Muscle Ultrasound as a Marker of Progression in Children With Muscular Diseases

Duchenne Muscular Dystrophy Clinical Trial

Official title:
Quantitative Muscle Ultrasound as a Monitoring Tool of Disease Progression in Children With Inflammatory Myositis and Duchenne Muscular Dystrophy

Clinical Trial Summary

The aim of our study is to Assess skeletal muscle structural status in children with inflammatory myositis and Duchenne muscular dystrophy using musculoskeletal ultrasound and to perform a longitudinal follow up of these changes over 2 years and to assess the relation between these findings with clinical parameters, functional scales, biochemical and electromyographic tests.

Clinical Trial Description

This study will be carried out on two groups:

• Group (I): fifty children diagnosed to have duchenne muscular dystrophy and inflammatory myositis.

Group (II): including 20 healthy children matching age and sex as control group.

patients will be subjected to

(A) Clinical evaluation

1. Complete history taking.

2. Thorough clinical examination.

3. Body mass index (BMI) assessment.

4. Quantitative muscle strength tests

5. Functional grading

6. Childhood Myositis Assessment Scale. 7 (B) Laboratory assessment:

All patients will be subjected to the following measurements:

1. Serum creatine kinase levels (CK).

2. Serum Lactate dehydrogenase levels

3. Serum of Liver enzymes (SGOT& SGPT) levels.

(C) Electromyographic (EMG) assessment:

(D) Musculoskeletal ultrasound assessment (E) Statistical analysis ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03786913
Study type Observational
Source Benha University
Contact
Status Completed
Phase
Start date March 8, 2016
Completion date February 2, 2019
View Details
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