Aerobic Exercise in Boys With Duchenne Muscular Dystrophy (DMD)

Status Completed

Clinical Trial Summary

This research study wants to learn more about Duchenne Muscular Dystrophy (DMD) and exercise. Today it is unknown how exercising impacts boys with DMD. The investigators believe that increasing activity and aerobic exercise may help with heart, lung, and muscle function. The investigators are hoping to compare physical strength and blood samples of boys with DMD to see if there are any differences between kids who exercised more as a child versus those who didn't.

Clinical Trial Description

Recently, the American Academy of Neurology released new guidelines for children with Duchenne Muscular Dystrophy (DMD) with an updated recommendation to include moderate aerobic exercise. Historically, children with DMD were advised to not exercise as it was thought to accelerate muscle loss. Today, there is new data suggesting that moderate aerobic exercise that does not strain muscle may be beneficial and improve a child's quality of life with regard to heart disease, fatigue, and other factors of overall health. Although it is expected that children who exercise will experience health benefits, there is no scientific evidence indicating a positive or negative effect in a DMD population.

This study is trying to understand the role of aerobic exercise in boys with DMD and how it may impact heart, muscle, and lung function using newly identified biomarkers. The goal is to correlate increased aerobic exercise with improved functional outcomes and changes in biomarkers.

The data collected from this study will allow future development and implementation of an innovative and disease-specific home aerobic exercise program that in the future will be recommended to families of children with DMD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03319030
Study type	Observational
Source	Ann & Robert H Lurie Children's Hospital of Chicago
Contact
Status	Completed
Phase
Start date	September 1, 2017
Completion date	September 30, 2018

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05575648` - Dual Task in Duchenne Muscular Dystrophy	N/A
Terminated	`NCT03907072` - Efficacy and Safety Study of WVE-210201 (Suvodirsen) With Open-label Extension in Ambulatory Patients With Duchenne Muscular Dystrophy	Phase 2/Phase 3
Not yet recruiting	`NCT06450639` - An Open-label Study to Assess the Efficacy and Safety of Satralizumab in Duchenne Muscular Dystrophy	Phase 2
Completed	`NCT04335942` - Characterization of the Postural Habits of Wheelchair Users Analysis of the Acceptability of International Recommendations in the Prevention of Pressure Sores Risk by Using a Connected Textile Sensor	N/A
Active, not recruiting	`NCT04906460` - Open-label Study of WVE-N531 in Patients With Duchenne Muscular Dystrophy (FORWARD-53)	Phase 1/Phase 2
Active, not recruiting	`NCT02500381` - Study of SRP-4045 (Casimersen) and SRP-4053 (Golodirsen) in Participants With Duchenne Muscular Dystrophy (DMD)	Phase 3
Enrolling by invitation	`NCT05967351` - A Long-term Follow-up Study of Participants Who Received Delandistrogene Moxeparvovec (SRP-9001) in a Previous Clinical Study	Phase 3
Recruiting	`NCT03067831` - Bone Marrow-Derived Autologous Stem Cells for the Treatment of Duchenne Muscular Dystrophy	Phase 1/Phase 2
Recruiting	`NCT01834040` - Study Safety and Efficacy of BMMNC for the Patient With Duchenne Muscular Dystrophy	Phase 1/Phase 2
Completed	`NCT02246478` - A Study of TAS-205 for Duchenne Muscular Dystrophy	Phase 1
Active, not recruiting	`NCT01772043` - Duchenne Muscular Dystrophy Tissue Bank for Exon Skipping	N/A
Terminated	`NCT01168908` - Revatio for Heart Disease in Duchenne Muscular Dystrophy and Becker Muscular Dystrophy	Phase 2
Completed	`NCT00758225` - Long-term Safety, Tolerability and Efficacy of Idebenone in Duchenne Muscular Dystrophy (DELPHI Extension)	Phase 2
Completed	`NCT03680365` - Your Voice; Impact of Duchenne Muscular Dystrophy (DMD) on the Lives of Families
Recruiting	`NCT03513367` - The Validation Process for Confirmation of the French Version of the Pediatric Quality of Life Inventory :PedsQLTM.
Recruiting	`NCT05712447` - Duchenne Muscular Dystrophy Video Assessment Registry
Recruiting	`NCT01484678` - Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy
Terminated	`NCT01753804` - A Prospective Natural History Study of Progression of Subjects With Duchenne Muscular Dystrophy.	N/A
Completed	`NCT02530905` - Dose-Titration and Open-label Extension Study of SRP-4045 in Advanced Stage Duchenne Muscular Dystrophy (DMD) Patients	Phase 1
Terminated	`NCT04708314` - An Open-Label Study of Golodirsen in Non-Ambulant Patients With Duchenne Muscular Dystrophy	Phase 4