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Safety and Efficacy Study of IGF-1 in Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy Clinical Trial

Official title:
IGF-1 Therapy and Muscle Function in Duchenne Muscular Dystrophy

Clinical Trial Summary

The purpose of this study is to determine whether IGF-1 therapy improves or preserves muscle function in Duchenne Muscular Dystrophy (DMD).

Clinical Trial Description

Detailed Description: DMD is a progressive degenerative muscle disorder for which there is no current cure. Glucocorticoids (GC) are often used to improve motor function and survival but have significant side effects such as growth failure, weight gain, insulin resistance and osteoporosis. IGF-1 stimulates both the proliferation and differentiation of skeletal muscle cells and is thus important for muscle repair and regeneration. IGF-1 offers potential as a therapeutic agent for DMD as it may improve or preserve motor function and reduce GC side effects such as growth failure and insulin resistance. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01207908
Study type Interventional
Source Children's Hospital Medical Center, Cincinnati
Contact
Status Completed
Phase Phase 1/Phase 2
Start date November 2010
Completion date June 2013
View Details
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