Dry Socket Clinical Trial
Official title:
The Influence of Intra-alveolar Application of Honey on Healing Following Molar Teeth Extraction: A Randomized Clinical Trial
A prospective randomized parallel trial will be carried out on 100 patients who have
extraction of single molar tooth. Teeth extractions will be done under local anesthesia. The
patients will be divided randomly into two parallel groups. Group 1: The patients will start
using Chlorhexidine mouthwash on the second day of extraction twice daily for 7 days. Group
2: After extraction, Manuka Honey will be applied topically into the extraction socket.
Postoperative instructions will be given for all patients in addition to the prescription of
ibuprofen 600 mg every 8 hours for 3 days.
Re-evaluation:
Postoperative day 3: tenderness with probing the socket, empty socket, food debris,
halitosis and assessment of pain. For group 2, the intra-alveolar application of honey will
be repeated. Re-evaluation will be repeated in the seventh post-operative day. Acute
alveolar osteitis, (dry socket) is diagnosed if the patient presented between the 2nd and
4th days with pain or tenderness in the socket with probing, empty socket and food debris
with or without halitosis.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | August 2017 |
Est. primary completion date | June 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 60 Years |
Eligibility |
Inclusion criteria: - Patients who have extraction of single molar tooth Exclusion criteria: - Patients with uncontrolled systemic diseases - Pregnant women - Breastfeeding women - Women are using oral contraceptives - Allergy to chlorhexidine - Allergy to honey - Presence of acute infection, cystic lesions - Traumatic extraction - Extraction requiring bone reduction - Extractions lasted more than 30 minutes |
Country | Name | City | State |
---|---|---|---|
Saudi Arabia | RiyadH Colleges of dentistry and Pharmacy | Riyadh |
Lead Sponsor | Collaborator |
---|---|
Riyadh Colleges of Dentistry and Pharmacy |
Saudi Arabia,
Abu-Mostafa NA, Alqahtani A, Abu-Hasna M, Alhokail A, Aladsani A. A randomized clinical trial compared the effect of intra-alveolar 0.2 % Chlorohexidine bio-adhesive gel versus 0.12% Chlorohexidine rinse in reducing alveolar osteitis following molar teeth extractions. Med Oral Patol Oral Cir Bucal. 2015 Jan 1;20(1):e82-7. — View Citation
Alexander RE. Dental extraction wound management: a case against medicating postextraction sockets. J Oral Maxillofac Surg. 2000 May;58(5):538-51. Review. — View Citation
Atwa AD, AbuShahba RY, Mostafa M, Hashem MI. Effect of honey in preventing gingivitis and dental caries in patients undergoing orthodontic treatment. Saudi Dent J. 2014 Jul;26(3):108-14. doi: 10.1016/j.sdentj.2014.03.001. — View Citation
Bloomer CR. Alveolar osteitis prevention by immediate placement of medicated packing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Sep;90(3):282-4. — View Citation
Caso A, Hung LK, Beirne OR. Prevention of alveolar osteitis with chlorhexidine: a meta-analytic review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Feb;99(2):155-9. — View Citation
Efem SE. Clinical observations on the wound healing properties of honey. Br J Surg. 1988 Jul;75(7):679-81. — View Citation
Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N. Honey as a topical treatment for wounds. Cochrane Database Syst Rev. 2015 Mar 6;(3):CD005083. doi: 10.1002/14651858.CD005083.pub4. Review. — View Citation
Nasir NA, Halim AS, Singh KK, Dorai AA, Haneef MN. Antibacterial properties of tualang honey and its effect in burn wound management: a comparative study. BMC Complement Altern Med. 2010 Jun 24;10:31. doi: 10.1186/1472-6882-10-31. — View Citation
Pieper B. Honey-based dressings and wound care: an option for care in the United States. J Wound Ostomy Continence Nurs. 2009 Jan-Feb;36(1):60-6; quiz 67-8. doi: 10.1097/01.WON.0000345177.58740.7d. — View Citation
Singh V, Pal US, Singh R, Soni N. Honey a sweet approach to alveolar osteitis: A study. Natl J Maxillofac Surg. 2014 Jan;5(1):31-4. doi: 10.4103/0975-5950.140166. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Pain day 3 | Assessment of pain by (VAS) from (0, 1, 2,….10). | on the 3rd day | |
Secondary | Empty socket day 3 | By inspection. The socket is empty and does not contain blood clot | on the 3rd day | |
Secondary | Empty socket day 7 | By inspection. The socket is empty and does not contain blood clot | in the 7th day | |
Secondary | Tenderness within the socket day 3 | By probing the socket | on the 3rd day | |
Secondary | Tenderness within the socket day 7 | By probing the socket | on the 7th day | |
Secondary | Pain day 7 | Assessment of pain by (VAS) from (0, 1, 2,….10). | on the 7th day |
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