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Oral Pilocarpine in the Treatment of the Dry Eye of Patients With Sjogrens Syndrome

Dry Eye Clinical Trial

Official title:
Oral Pilocarpine in the Treatment of the Dry Eye of Patients With Sjogrens Syndrome

Clinical Trial Summary

The purpose of this study was to access the possible beneficial effects of oral use of pilocarpine in relieving signs and symptoms of patients with Sjogren's syndrome

Clinical Trial Description

After being informed about the study, its potential risks and having signed the informed consent form, this placebo-controlled, crossover study involved patients with Sjögren's syndrome to use oral pilocarpine or placebo for ten weeks and after two weeks of medication withdrawal, to invert the treatment for the same period of time. The assessments applied were the Ocular Surface Disease Index, NEI-VFQ-25 questionnaire, non-invasive break-up time, traditional break-up time, evaluation of the cornea and ocular surface with fluorescein and rose bengal dyes, Schirmer test, and tear ferning test. Side effects observed during the treatment period were also assessed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04470479
Study type Interventional
Source Federal University of São Paulo
Contact
Status Completed
Phase Phase 3
Start date March 1, 2005
Completion date April 1, 2006
View Details
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