Dry Eye Clinical Trial
Official title:
Evaluation of Xanthan Gum Eye Drops in Patients With Dry Eye
The purpose of this study is to evaluate the effect of an ophthalmic solution containing 0.2% xanthan gum in reducing symptoms and signs of dry eye as well as tear film markers of oxidative stress.
Oxidative stress is the result of an imbalance between the production of reactive oxygen
species (ROS) and antioxidant systems . The eye is constantly exposed to solar UV radiation
which is the major inducer of ROS production and therefore oxidative stress has been
implicated in the pathogenesis of several eye disease, including dry eye. Xanthan gum is a
complex exopolysaccharide utilized as a food additive. Its chemical structure shows a
capacity to react with ROS indicating a role as an anti-oxidative molecule.
In the present study aging patients with dry eye will be enrolled. Signs and symptoms of dry
eye as well as levels of oxidative stress in tear will be evaluated afte 30 days of
treatment with eye drops containing carboxymethylcellulose or xanthan gum.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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