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Dry Eye clinical trials

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NCT ID: NCT00893139 Completed - Dry Eye Clinical Trials

A Study of AL-38583 Ophthalmic Solution 0.05%, 0.010% Versus AL-38583 Vehicle for Dry Eye

Start date: June 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether AL-38583 ophthalmic solution is effective for treatment of signs and symptoms of dry eye.

NCT ID: NCT00854906 Completed - Dry Eye Clinical Trials

Keratometric Tear Breakup Time and Fluorescein Tear Breakup Time

Start date: February 2009
Phase: N/A
Study type: Observational

The purpose of the research is to determine if putting fluorescein onto the eye (most common test done for dry eye syndrome) is an accurate way to measure dry eye symptoms. The investigators can avoid placing any foreign substance into the eye by using a manual keratometer. Therefore, the investigators want to compare the measurements of tear breakup time using fluorescein with using a novel method, a manual keratometer and then compare these measurements to a validated dry eye symptoms questionnaire. All qualifying patients who were scheduled in the Jones Eye Institute Clinics for a complete eye exam were offered information about the study and invited to participate. Participants were recruited from February 29, 2009 to April 14, 2009.Participants who did not meet the study protocol's inclusion and exclusion criteria were not included the study or study data analysis. All subjects eyes were measured for KTBUT and FTBUT.

NCT ID: NCT00848068 Completed - Dry Eye Clinical Trials

Evaluation of FID 114657 on Tear Film Lipid Layer Thickness

Start date: January 2009
Phase: N/A
Study type: Interventional

To evaluate the effects of FID 114657 on the tear film lipid layer thickness of patients with dry eye.

NCT ID: NCT00840268 Completed - Dry Eye Clinical Trials

A Study of Hydroxypropyl Guar Galactomannan 0.25% (HPGG) Versus Vehicle in Dry Eye Patients

Start date: February 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to demonstrate efficacy of Hydroxypropyl Guar Galactomannan 0.25% (HPGG) ophthalmic gel compared to Vehicle for the treatment of dry eye.

NCT ID: NCT00833235 Completed - Dry Eye Clinical Trials

A Natural History Study of Patients With Dry Eye

Start date: February 1, 2009
Phase: N/A
Study type: Observational

This is a multi-center, prospective, controlled, observational study of the natural history of patients with dry eye disease.

NCT ID: NCT00814944 Completed - Dry Eye Clinical Trials

A Dose-Ranging Clinical Study to Assess the Safety and Efficacy of Subconjunctival Injection of Sirolimus in Patients With Dry Eye in the Controlled Adverse Environmental (CAE) Model

Start date: April 2009
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine the safety and efficacy of an ocular sirolimus (rapamycin) formulation compared to Placebo on the signs and symptoms of dry eye in the CAE Model.

NCT ID: NCT00809198 Completed - Dry Eye Clinical Trials

Kynex Versus Refresh Plus Study in Subject With Dry Eye

Start date: December 2008
Phase: Phase 4
Study type: Interventional

The effect of Kynex versus Refresh Plus in subjects with mild to moderate dry eye.

NCT ID: NCT00809003 Completed - Dry Eye Clinical Trials

Assessment of Inflammatory and Functional Changes in the Ocular Surface Associated With Dry Eye Disease

JADE
Start date: September 2007
Phase: N/A
Study type: Observational

This project will examine the similarities and differences of the ocular surface and tear film in patients with Sjogren's syndrome related to dry eye, severe dry eye and those who do not have dry eye. This knowledge will help clinicians understand the processes that create these dry eye conditions and will strengthen the treatment and management strategies that will be used. The subjects will participate in a series of dry eye tests that they have already experienced in clinic, along with the gathering of tear samples and surface cells. These tissues will then be analyzed at a distant site.

NCT ID: NCT00804791 Completed - Dry Eye Clinical Trials

Residence Time Evaluation of Marketed OTC Ophthalmic Products

Start date: November 2008
Phase: N/A
Study type: Interventional

The objective of this study is to measure ocular surface residence time (in minutes) of two marketed OTC ophthalmic products in dry eye patients.

NCT ID: NCT00802399 Completed - Dry Eye Clinical Trials

Partial Lacrimal Punctual Occlusion

PLPO
Start date: September 2008
Phase: N/A
Study type: Interventional

The purpose of this study is to describe a case series of patients with chronic dry eye submitted to partial punctual occlusion.