Tear Lipid Layer Thickness With Emollient Eye Drops

Status Completed

Clinical Trial Summary

Crossover comparison of lipid layer thickness with two artificial tear formulations

Clinical Trial Description

This study will objectively evaluate two US Monograph lubricant eyedrop formulations (Allergan, plc). Refresh Optive ADVANCED will be compared to an investigational formula with additional compendial ingredients (Refresh Optive MEGA 3) in subjects with dry eye symptoms and lipid layer thickness < 75 nm at baseline in a randomized, cross-over (masked subject) design. We seek to objectively evaluate the increase in lipid layer thickness from baseline at 15 minutes and 1 hour after each eye drop has been instilled. The Stroboscopic Video Color Microscope of King-Smith is used for non-invasive lipid layer thickness measurement. ;

Study Design

Related Conditions & MeSH terms

Dry Eye Syndromes

Clinical Trial Details

NCT number	NCT03380624
Study type	Interventional
Source	Ohio State University
Contact
Status	Completed
Phase	Phase 4
Start date	March 1, 2017
Completion date	June 30, 2018

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