Dry Eye Syndromes Clinical Trial
The "dry eye syndrome" DES is a highly prevalent ocular disease, in particular in the
elderly population. One mainstay of therapy for patients suffering from DES is the use of
topically administered lubricants. However, despite many efforts, no "ideal" formulation has
yet been found.
Recently, Croma Pharma has introduced chitosan-N-acetylcysteine eye drops, designed for
treatment of symptoms related to DES. Chemically, chitosan is a polycationic biopolymer with
favourable biological properties such as high biocompatibility and low toxicity.
Additionally, the new formulation comprises N-acetylcysteine, which has been used in
ophthalmology because of its mucolytic properties for several years. Based on theoretical
considerations, one can hypothesize that the new chitosan derivative may show an increased
adhesion to mucins of the ocular surface and may therefore be particularly beneficial in
reducing the symptoms associated with DES.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Basic Science
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