Medication Reviews in Elderly in Primary Care

Drug Utilization Review Clinical Trial

Official title:

The Impact of Medication Reviews Conducted in Primary Care on Hospital Admissions and Mortality - a Randomized Controlled Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04040855
• Other study ID #: 2018/8
• Status: Completed
• Phase: N/A
• Start date: September 1, 2011
• Est. completion date: March 31, 2019

Study information

• Verified date: July 2019
• Source: Region Skane
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study is a follow-up of a randomized controlled study performed in 2011-2012 with medication reviews in elderly patients in Sweden. Additional data about mortality and hospital admissions have been collected.

Description:

Background Drug-related problems among the elderly population are common and increasing. Multi-professional medication reviews (MR) have arisen as a method to optimize drug therapy for frail elderly patients. Research has not yet been able to show conclusive evidence of the effect of MRs on mortality or hospital admissions. Aim The aim of this study was to assess the impact of MRs' on hospital admissions and mortality after six and 12 months in a frail population of 369 patients in primary care in a randomized controlled study. Methods Patients were blindly randomized to an intervention group (receiving MRs) and a control group (receiving usual care). Descriptive data on mortality and hospital admissions at six and 12 months were collected. Survival analysis was performed for time to death and time to the first hospital admission within 12 months.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 369
• Est. completion date: March 31, 2019
• Est. primary completion date: December 31, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 75 Years and older

Eligibility

Inclusion Criteria:

• age>75 years, living in nursing homes or community-dwelling with municipality-provided care, with multi-dose drug dispensing

Exclusion Criteria:

• lack of multi-dose drug dispensing, living at home with no municipality-provided care, <75 years old

Related Conditions & MeSH terms

• Drug Utilization Review

Intervention

Other:
• Medication review
Multi-professional medication review

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Region Skane

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	number of drugs	number of drugs	base-line
Primary	hospital admission	time to the first hospital admission	six months
Primary	hospital admission	time to the first hospital admission	twelve months
Primary	Survival analysis	time to death	six months
Primary	Survival analysis	time to death	twelve months
Secondary	number of hospital admissions	number of hospital admissions	six months
Secondary	number of hospital admissions	number of hospital admissions	twelve months
Secondary	mortality	number of deaths	six months
Secondary	mortality	number of deaths	twelve months