Colonic Neoplasms Clinical Trial
Official title:
Neoadjuvant FOLFOXIRI (Irinotecan, Oxaliplatin and Fluorouracil) Chemotherapy in Patients With Locally Advanced Colon Cancer：an Open-label, Single-arm, Multicenter Phase II Study
To evaluate the efficacy and safety of neoadjuvant FOLFOXIRI chemotherapy (irinotecan, oxaliplatin and fluorouracil) in the patients with locally advanced colon cancer.
For the patients with locally advanced colon cancer, adjuvant FOLFOX and XELOX chemotherapy have become standard treatment. However, 30% - 40% patients suffered from local recurrence or distant metastasis after this standard treatment. Neoadjuvant chemotherapy could shrink tumors, eliminate micrometastasis, reduce surgical trauma and accelerate recovery. Hence, we evaluate the efficacy and safety of FOLFOXIRI as neoadjuvant chemotherapy in treating patients with locally advanced colon cancer. In this prospective study, 30 patients with locally advanced colon cancer will be treated with 4 cycles of neoadjuvant FOLFOXIRI chemotherapy followed by surgical resection. PET-CT scanning will be performed before and after the neoadjuvant FOLFOXIRI chemotherapy to assess SUVmax changes. The ctDNA in peripheral blood before and after each cycle of neoadjuvant FOLFOXIRI chemotherapy will be detected. In the course of treatment, safety evaluation will be carried out according to adverse reaction classification (CTCAE) 4. 0. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03746353 -
Early Closure Versus Conventional Closure in Postoperative Patients With Low Anteriresection for Rectal Cancer
|
N/A | |
| Recruiting |
NCT05809999 -
IBD Neoplasia Surveillance RCT
|
N/A | |
| Recruiting |
NCT06041945 -
Artificial Intelligence to Implement Cost-saving Strategies for Colonoscopy Screening Based on in Vivo Prediction of Polyp Histology
|
N/A | |
| Not yet recruiting |
NCT02688699 -
Additive Hemostatic Efficacy of EndoClot After EMR or ESD in the Gastrointestinal Tract
|
Phase 4 | |
| Not yet recruiting |
NCT03175146 -
A Study to See Whether Stereotactic Body RadioTherapy (SBRT) Can Shrink Tumours Within the Liver Safely
|
N/A | |
| Completed |
NCT02529007 -
Endo-cuff Assisted Vs. Standard Colonoscopy for Polyp Detection in Bowel Cancer Screening
|
N/A | |
| Not yet recruiting |
NCT01929499 -
Efficacy of Adjuvant Cytokine-induced Killer Cells in Colon Cancer
|
Phase 2 | |
| Completed |
NCT01681472 -
PK/PD Investigation of Modufolin (Arfolitixorin) in Plasma, Tumor and Adjacent Mucosa Adjacent Mucosa in Patients With Colon Cancer
|
Phase 1/Phase 2 | |
| Completed |
NCT01438645 -
ScopeGuide-assisted Colonoscopy Versus Conventional Colonoscopy
|
N/A | |
| Completed |
NCT00535652 -
Concentration of Ertapenem in Colorectal Tissue
|
Phase 4 | |
| Terminated |
NCT00267787 -
Molecular Genetic and Pathological Studies of Anal Tumors
|
||
| Completed |
NCT05498051 -
Fluorescent Sentinel Lymph Node Identification in Colon Carcinoma Using Submucosal Bevacizumab-800CW.
|
N/A | |
| Recruiting |
NCT05068180 -
Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients
|
Phase 4 | |
| Recruiting |
NCT03314896 -
Laparoscopic Surgery for T4 Tumor of the Colon Cancer (LST4C Trial)
|
N/A | |
| Not yet recruiting |
NCT02852915 -
Laparoscopic Surgery for T4 Tumor of the Colon Cancer
|
Phase 3 | |
| Not yet recruiting |
NCT02777437 -
Laparoscopic Surgery VS Laparoscopic Surgery + Neoadjuvant Chemotherapy for T4 Tumor of the Colon Cancer
|
Phase 2/Phase 3 | |
| Completed |
NCT00997802 -
Japanese National Computed Tomographic (CT) Colonography Trial
|
N/A | |
| Completed |
NCT01056913 -
NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery
|
Phase 4 | |
| Completed |
NCT00537901 -
First-Line Bevacizumab and Chemotherapy in Metastatic Cancer of the Colon or Rectum - International Study
|
N/A | |
| Completed |
NCT00470782 -
Aerobic Capacity and Body Composition in Colon Cancer Patients
|
N/A |