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Drug Resistant Epilepsy clinical trials

View clinical trials related to Drug Resistant Epilepsy.

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NCT ID: NCT06341075 Enrolling by invitation - Clinical trials for Drug Resistant Epilepsy

Real-World Study of Magnetic Resonance-guided Laser Interstitial Thermal Therapy for Drug-resistant Epilepsy

Start date: March 14, 2024
Phase: N/A
Study type: Interventional

The goal of the real-world study is to evaluate the long-term seizure control outcomes, postoperative complications, long term impact on cognitive, memory function outcomes, quality-of-life measures, and healthcare resource utilization of magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) on patients with drug-resistant epilepsy (DRE).

NCT ID: NCT06138808 Enrolling by invitation - Clinical trials for Epilepsy Intractable

5-SENSE Score Validation Study

Start date: January 9, 2024
Phase:
Study type: Observational

The purpose of this study is to assess how well a new scoring system called the 5-SENSE score can predict where seizures start in the brain using Stereoelectroencephalography (SEEG). The 5-SENSE Score is a 5-point score based on routine presurgical work-up, designed to assist in predicting whether SEEG can identify a focal seizure onset zone, thereby sparing patients the risk of undergoing this invasive diagnostic procedure.

NCT ID: NCT05958069 Enrolling by invitation - Clinical trials for Epileptic Seizures Related to Drugs

The Efficacy and Safety of Minocycline in the Treatment of Drug-resistant Epilepsy in NORSE Patients

Start date: March 1, 2023
Phase: N/A
Study type: Interventional

Exploring the efficacy and safety of oral minocycline combined with antiepileptic drugs in the treatment of drug-resistant epilepsy in NORSE patients, obtaining preliminary research data, and providing evidence and data support for the next large-scale randomized controlled clinical study.

NCT ID: NCT05332990 Enrolling by invitation - Clinical trials for Epilepsy Intractable

Multicenter Comparison of Interictal HFO as a Predictor of Seizure Freedom

multiHFO
Start date: May 1, 2022
Phase:
Study type: Observational

In drug-resistant focal epilepsy, interictal high frequency oscillations (HFO) recorded from intracranial EEG (iEEG) may provide clinical information for delineating epileptogenic brain tissue. The iEEG electrode contacts that contain HFO are hypothesized to delineate the epileptogenic zone; their resection should then lead to postsurgical seizure freedom. We test whether our prospective definition of clinically relevant HFO is in agreement with postsurgical seizure outcome. The algorithm is fully automated and is equally applied to all datasets. The aim is to assess the reliability of the proposed detector and analysis approach.

NCT ID: NCT05273970 Enrolling by invitation - Cognition Clinical Trials

Electrochemical and Electrophysiological Study

Start date: September 7, 2022
Phase: N/A
Study type: Interventional

This study will utilize computerized algorithms in combination with real-time intracranial neurophysiological and neurochemical recordings and microstimulation to measure cognitive and affective behavior in humans. Questionnaires or simple behavioral tasks (game-like tasks on a computer or an iPad) may also be given to additionally characterize subjects on related cognitive or affective components. Importantly, for the purposes of understanding the function of the human brain, neural activity can be recorded and probed (i.e. microstimulation) while subjects are performing the same computerized cognitive and affective tasks. These surgeries allow for the in vivo examination of human neurophysiology and are a rare opportunity for such research. In addition to computerized testing, the investigators plan to characterize subjects' behavior on related cognitive or affective components. Some neuropsychological questionnaires, many of which are administered for clinical reasons (listed below under study population), may also be given to patients and healthy control subjects. All patients undergoing epilepsy surgery (the population from which subjects will be selected) undergo a standard clinical neuropsychological battery to assess aspects of cognitive function. This is a regular aspect of their clinical assessment carried out prior to consideration for study inclusion. All participants are selected uniformly because they are undergoing surgery for subdural electrode implantation. No particular ethnic group or population is targeted by or excluded from the study. Those to be considered for inclusion in the proposed study performing more than 2 standard deviations below the mean on any aspect of cognitive functioning as determined by standard preoperative neuropsychological testing will be excluded from the study. No additional neuropsychological testing will be necessary as part of the study itself.

NCT ID: NCT05248269 Enrolling by invitation - Epilepsy Clinical Trials

Thermocoagulation in Drug Resistant Focal Epilepsy

Start date: February 7, 2022
Phase: N/A
Study type: Interventional

Therapeutic thermocoagulation will be carried out in patients with drug-resistant focal epilepsy in cases where an epileptogenic zone is found and proven according to stereo-electroencephalography (SEEG) data.

NCT ID: NCT04500119 Enrolling by invitation - Clinical trials for Epilepsy Intractable

Neuronal Mechanisms of Human Episodic Memory

Start date: August 12, 2020
Phase: N/A
Study type: Interventional

The purpose the research is to better understand how the human brain accomplishes the basic cognitive tasks of learning new information, recalling stored information, and making decisions or choices about presented information. These investigations are critical to better understand human cognition and to design treatments for disorders of learning and memory.

NCT ID: NCT04286776 Enrolling by invitation - Clinical trials for Epilepsy Intractable

Memory Retrieval and Encoding Investigated by Neural Stimulation

MEMREINS
Start date: October 12, 2014
Phase: N/A
Study type: Interventional

The purpose of this research is to understand biomarkers of human memory through correlational analyses and to use focal electrical stimulation as a causal manipulation to understand how biomarkers of memory relate to other brain states and behavioral measures.

NCT ID: NCT03702127 Enrolling by invitation - Clinical trials for Epilepsy Intractable

TMS - Intracranial Electrodes

Start date: July 16, 2019
Phase: N/A
Study type: Interventional

This is a study looking at the effects of transcranial magnetic stimulation (TMS), a form of non-invasive brain stimulation (NIBS), on the human brain as recorded by intracranial electroencephalography in neurosurgical patients. NIBS will be applied in a targeted manner and brain responses will be recorded.