Drug-Related Problems Clinical Trial
Official title:
Optimizing Drug-Therapy in Patients, 80 Years and Older, in Order to Reduce Drug-Related Morbidity and Usage of Secondary Care - a Randomized Controlled Trial
The purpose of this study is to measure the effects of an enhanced service where a pharmacists is part of the healthcare team on the ward (focusing on drug-related problems and transferring information between primary and secondary care). Primary outcome measure is visits to hospital during a 12-month follow-up period, and the population is patients 80 years and older.
Optimising drug-therapy for patients, 80 years and older, to reduce hospital visits
Background and Objective:
Results from a pilot-study performed in 2004 at the Academic Hospital, Uppsala, including
214 consecutive patients (80 years old or older) showed that 9.4%-13.6% of the patients were
acutely admitted to hospital due to a drug related problem1. Other similar international
studies show that the frequency of drug-related hospital admissions stands for at least 14%
of the acute admissions (14%-30.4%). Of these admissions it was estimated that 32%-69% were
preventable 2,3,4.
A study from Antrim Hospital, Northern Ireland, showed that pharmacists´ involvement in the
health care team can reduce the number of acute hospital admissions and improve quality of
drug use5.
In view of these findings this study was initiated in 2005 with fundings from the Drug and
Therapeutics committee, the County Council of Uppsala, the Division of Acute-Medicine and
the Pharmacy Department at the Academic Hospital in Uppsala
Aim and objectives:
The Study Aim was to optimize drug-prescribing and drug use for patients 80 years and older.
The main objective was to reduce the number of hospital visits for patients 80-years old or
older.
Design:
A randomized, controlled trial including 400 patients (200+200). Patients in the
intervention group (I) received a patient interview on admission, drug counseling on
discharge and a drug review - all performed by a clinical pharmacist. Patients in the
control group (C) received standard care, without pharmacists´ involvement.
Patients were included between Oct 2005 and June 2006.
Setting:
Two wards at the Division of Acute-Medicine at Uppsala University Hospital, Sweden
Main Outcome Measures:
1) Frequency of hospital visits 12 months after (last included patient) discharge from
hospital for (I) and (C).
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Health Services Research
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