Social Network Overdose Prevention and Education Intervention

Drug Overdose Clinical Trial

Official title:

A Social Diffusion Fatal Overdose Prevention Intervention: Assessing the Effectiveness of People Who Use Opioids as Peer Educators in Training Using & Non-using Networks on Overdose & Stigma Reduction

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06327061
• Other study ID #: R01DA058659
• Secondary ID: IRB00026607
• Status: Not yet recruiting
• Phase: N/A
• Start date: June 1, 2024
• Est. completion date: December 1, 2027

Study information

• Verified date: April 2024
• Source: Johns Hopkins Bloomberg School of Public Health
• Contact: Carl Latkin, PhD
• Phone: (410)955-3972
• Email: carl.latkin[@]jhu.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to test a social intervention focused on overdose prevention and care. In the investigators prior work, the investigators have shown that people who use opioids (PWUO) can be effective peer educators (PEs).

Description:

The purpose of this study is to test a social intervention focused on overdose prevention and care. In the investigators prior work, the investigators have shown that people who use opioids (PWUO) can be effective peer educators (PEs). The investigators have utilized PEs for overdose prevention in interventions that have focused on training network members who use drugs to respond to an overdose. Yet, many overdoses are witnessed by people who do not use drugs. Additionally, many PWUO report using drugs at home and living with someone who does not use drugs, which highlights the importance of training non-using network members on overdose response. Based on pilot data, the investigators propose expanding an overdose peer education intervention to focus on non-using network members. The intervention seeks to prepare network members to respond to an overdose and normalize discussions about overdose prevention planning between index PWUO and non-using network members. The intervention condition consists of 3 individual sessions focused on overdose prevention and response. This condition is designed to train index study participants to be Peer Educators. In addition to the three sessions, the non-drug using network member will be offered one session. The control condition is only 1 session focused on overdose prevention and response. Both intervention and control participants will invite social network members to take part in data collection activities

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 600
• Est. completion date: December 1, 2027
• Est. primary completion date: June 1, 2027
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• self-reported illicit opioid use at least 2 times in the past two weeks;
• age 18 and older;
• living in the Baltimore metropolitan region;
• willing to engage in peer education; and
• having and willing to recruit at least one non-using network member. Exclusion Criteria: Participants without the cognitive ability to provide informed consent and have the physical ability to participate in in-person intervention sessions.

Related Conditions & MeSH terms

• Drug Overdose

Intervention

Behavioral:
• Network overdose prevention
Participants are taught overdose prevention methods with network members.
• Standard of care health education
Participants will receive the standard of care for overdose prevention.

Locations

Country	Name	City	State
United States	Johns Hopkins Bloomberg School of Public Health	Baltimore	Maryland

Sponsors (2)

Lead Sponsor	Collaborator
Johns Hopkins Bloomberg School of Public Health	National Institute on Drug Abuse (NIDA)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of drug overdoses	Number of drug overdoses in prior three months	3-months
Primary	Participant drug use	Proportion of times participants tested positive for drugs of fentanyl and xylazine using test strips in the prior 3 months.	3-months
Secondary	Number of Network member contacts	Number of network members talked to about overdose prevention in prior 3 months	3-months