Drug Mechanism Clinical Trial
Official title:
Pharmacokinetics and Pharmacodynamics of Extended-Infusion Cefepime in Continuous Renal Replacement Therapy
This prospective, multi-center study aims to determine the pharmacokinetics and pharmacodynamics of extended-infusion cefepime in continuous renal replacement therapy (CRRT).
This prospective, multi-center study aims to determine the pharmacokinetics and pharmacodynamics of extended-infusion cefepime in CRRT. Patients on CRRT who are being initiated on cefepime 2000 mg IV every eight hours with a four-hour infusion will be considered for enrollment. Pre- and post-membrane serum levels will be drawn at scheduled intervals for both the first dose and again during another dose at steady state. Concomitant effluent and urine levels will also be obtained. A pharmacokinetic analysis will be performed and Monte Carlo simulations will be used to determine the probability of target attainment for various pharmacodynamic endpoints. Documented organism MICs will be used to determine the cumulative fraction of response. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04659343 -
TDM for Optimized Outcome in Patients With mRCC.
|
||
| Recruiting |
NCT01565759 -
In Vivo Lithium Treatment Effects on Gene Expression Levels in Lymphoblastoid Cell Lines From Human Healthy Subjects
|
Phase 1 | |
| Completed |
NCT01963130 -
Does Vildagliptin Affect Portal Vein Pressure In Patients With Type 2 Diabetes Mellitus? A Cross Sectional Study
|
N/A | |
| Completed |
NCT04690673 -
Detection of Paracetamol Concentration in Blood-, Saline- and Urine Samples - a Validation Study for a Novel Technique
|
N/A | |
| Recruiting |
NCT05212389 -
The Pill Project - Oral Contraceptive and Serotonergic Brain Signaling
|
N/A |