Clinical Trials Logo
  1. Home
  2. Drug Interactions
  3. NCT01886209

Phase 1 PK Interaction Study Between VX-509 and Prednisone or Methylprednisolone in Healthy Male Subjects

Drug Interactions Clinical Trial

Official title:
An Open-Label, Phase 1 Study to Examine the Pharmacokinetic Interactions Between VX-509 and Prednisone or Methylprednisolone in Healthy Male Subjects

Clinical Trial Summary

This study is designed to evaluate the effect of VX-509 on the pharmacokinetics (PK) of corticosteroids (prednisone or methylprednisolone) and the effect of corticosteroids on the PK of VX-509 and its metabolite. The study will also evaluate the safety and tolerability of VX-509 when coadministered with each of these corticosteroids.

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01886209
Study type Interventional
Source Vertex Pharmaceuticals Incorporated
Contact
Status Completed
Phase Phase 1
Start date June 2013
Completion date August 2013
View Details
See also
  Status Clinical Trial Phase
Completed NCT03686722 - Effect of Co-administration of Metformin and Daclatasvir on the Pharmacokinetis and Pharmacodynamics of Metformin Phase 1
Completed NCT01925638 - Effect of Ketoconazole on the Pharmacokinetics of Refametinib Phase 1
Completed NCT00621699 - Pharmacokinetic Drug Interaction Between Ezetimibe and Tacrolimus After Single Dose Administration in Healthy Subjects Phase 1
Completed NCT00442585 - S(+)-Ibuprofen Effects on Asprin Treated Volunteers Phase 1
Completed NCT00200759 - Drug Interactions and Bioavailability of Cranberry Phase 1
Active, not recruiting NCT06401863 - Shared Decision for Drug Interactions in Oral Anticoagulation N/A
Completed NCT00915746 - A Drug Interaction Study of JNJ-31001074 and Ketoconazole in Healthy Volunteers Phase 1
Completed NCT03748745 - A Drug-drug Interaction Study of SH229 Tablets and Daclatasvir Dihydrochloride Tablets in Healthy Subjects Phase 1
Completed NCT03324685 - A Drug Interaction Study of BIIB074 and an Oral Contraceptive Regimen Phase 1
Completed NCT05433896 - Evaluating the Effects of Omeprazole on the Pharmacokinetics of XS004 (Dasatinib) Tablets in Healthy Adult Subjects Under Fasting Conditions Phase 1
Recruiting NCT03307863 - Effect of Anti-epileptic Drugs on Etonogestrel-releasing Implant Pharmacokinetics in Women With Epilepsy Phase 4
Completed NCT02706535 - A Cross-over Study to Evaluate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics (PK) of GSK525762 in Healthy Female Subjects of Non Child Bearing Potential Phase 1
Completed NCT02147808 - A Open-Label Drug-Drug Interaction Study of Telotristat Etiprate and Midazolam in Healthy Subjects Phase 1
Completed NCT02097953 - Influence of Rifampin Co-Administration on the Pharmacokinetic Profile of Daptomycin Phase 0
Completed NCT01364987 - Pharmacokinetic Interaction Study to Assess the Effect of ASP015K on Mycophenolate Mofetil in Healthy Volunteers Phase 1
Completed NCT00709982 - A Drug Interaction Study of Folic Acid and Oral Contraceptive Tablets Containing Norgestimate (NGM) /Ethinyl Estradiol (EE) in Healthy Women. Phase 1
Completed NCT00810303 - Pharmacokinetic and Pharmacodynamic Interactions Between the Cholesterol-lowering Ezetimibe and the Non-nucleoside Reverse Transcriptase Inhibitor Efavirenz During Chronic Treatment in Healthy Volunteers With Reference to Intestinal Expression of CYP3A4, UGT1A1, ABCB1 and ABCC2 Phase 1
Completed NCT04252300 - Study to Learn the Effect of Drug BAY1817080 on the Way the Body Absorbs, Distributes and Excretes Another Drug Rosuvastatin in Healthy Adult Participants Phase 1
Completed NCT02576366 - Phenotypic Drug Probes as Predictors of Drug-drug Interactions With Tacrolimus Phase 4
Completed NCT02159326 - Microgynon Riociguat Drug Interaction Study in Healthy Postmenopausal Women Phase 1