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Assessment of Drug-drug Interactions Between Masculinizing Hormone Therapy and Antiretroviral Agents Concomitantly for Pre-exposure Prophylaxis Among Transgender Men

Drug Interaction Clinical Trial

Official title:
Institute of HIV Research and Innovation (IHRI)

Clinical Trial Summary

There are currently no published studies addressing drug-drug interactions (DDI) between masculinizing hormone therapy (MHT) and pre-exposure prophylaxis (PrEP) among transgender men (TGM). This could lead to concerns and subsequent prioritizing MHT over PrEP among TGM. Because tenofovir alafenamide (TAF) can achieve higher intracellular tenofovir diphosphate (TFV-DP) levels with lower tenofovir plasma concentrations, it is promising that both plasma tenofovir (TFV) and intracellular TFV-DP levels might not be significantly affected by MHT. The current study aims to determine the pharmacokinetics (PK) DDI between MHT and daily PrEP among TGM.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04593680
Study type Interventional
Source Thai Red Cross AIDS Research Centre
Contact Nittaya Phanuphak, MD, PhD
Phone 881 8253544
Email nittaya.p@ihri.org
Status Recruiting
Phase N/A
Start date October 1, 2020
Completion date October 1, 2025
View Details
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