Pharmacokinetics Clinical Trial
Official title:
Pharmacokinetic Interaction Between Trospium Chloride After Intravenous (2 mg) and Oral Administration (30 mg) With Ranitidine (300 mg p.o.) as an Inhibitor of OCT1 and With Clarithromycin (500 mg p.o.) as an Inhibitor of P-glycoprotein in 24 Healthy Subjects Genotyped for OCT1
The purpose of the study is:
- to determine absolute bioavailability, input rates, distribution volume, renal and
intestinal excretion of trospium in subjects with wild-type of SLC22A1 rs72552763 and
rs12208357 and in subjects with homozygous variant alleles of SLC22A1 rs72552763 or
rs12208357
- to determine absolute bioavailability, input rates, distribution volume and renal and
intestinal excretion of trospium in subjects with wild-type alleles of SLC22A1
rs72552763 and rs12208357 after co-medication of 300 mg of the OCT1- inhibitor
ranitidine
- to determine absolute bioavailability, input rates, distribution volume and renal and
intestinal excretion of trospium in subjects with wild-type alleles of SLC22A1
rs72552763 and rs12208357 after co-medication of 500 mg of the P-glycoprotein-
inhibitor clarithromycin
- to determine absolute bioavailability, input rates, distribution volume and renal and
intestinal excretion of trospium in subjects with homozygous variant alleles of SLC22A1
rs72552763 or rs12208357 after co-medication of 500 mg of the P-glycoprotein- inhibitor
clarithromycin.
n/a
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