The Effects of Sacubitril/Valsartan on the Heart Functions

Status Completed

Clinical Trial Summary

Background:

Sacubitril/valsartan, has been found to be more beneficial than enalapril for reducing the incidences of sudden cardiac death, death from worsening heart failure (HF), and hospitalization. However, there is no prospective echocardiographic data describing the effects of sacubitril/valsartan on the heart functions and left ventricular (LV) reverse remodeling. Therefore, the aim of our study was to evaluate the effects of sacubitril/valsartan on the LV functions using two dimensional (2D), three dimensional (3D) echocardiography and the 3D strain parameters.

Methods:

In 100 patients with HF with reduced ejection fraction (HRrEF) who have indications for the use of sacubitril/valsartan as recommended by recent guidelines were prospectively enrolled. The basal 2D and 3D echocardiographic parameters were compared to those obtained 3 months after starting the sacubitril/valsartan treatment.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Drug Effect

Clinical Trial Details

NCT number	NCT03830814
Study type	Observational [Patient Registry]
Source	The Young Investigator Group of Cardiovascular Research
Contact
Status	Completed
Phase
Start date	January 1, 2017
Completion date	July 31, 2018

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