Pupillary Response After Glaucoma Medication

Drug Effect (Glaucoma Drugs) Clinical Trial

— pupil  

Official title:

Effect of Topical Anti-glaucoma Medications on Late Pupillary Light Reflex, as Evaluated by Pupillometry

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02522039
• Other study ID #: GlostrupUH
• Status: Completed
• Phase: N/A
• First received: November 14, 2014
• Last updated: August 11, 2015
• Start date: May 2014
• Est. completion date: November 2014

Study information

• Verified date: August 2015
• Source: Glostrup University Hospital, Copenhagen
• Contact: n/a
• Is FDA regulated: No
• Health authority: Denmark: Ethical Comitte at Copenhagen Region
• Study type: Interventional

Clinical Trial Summary

Investigation of the effect on the pupillary constriction by latanoprost, dorzolamide,timolol in healthy subjects. The pupillary constriction is compared to no drug.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 21
• Est. completion date: November 2014
• Est. primary completion date: November 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• healthy subjects

Exclusion Criteria:

• ophthalmological diseases

• systemic disease

• smoking

• refractive error >= 6 diopters

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Drug Effect (Glaucoma Drugs)
• Glaucoma

Intervention

Drug:
• Latanoprost
1 drop of latanoprost was given to study eye after washout period of 1 week between drugs
• Timolol
1 drop of timolol was given to study eye after washout period of 1 week between drugs
• Dorzolamide
1 drop of dorzolamide was given to study eye after washout period of 1 week between drugs

Locations

Country	Name	City	State
Denmark	Glostrup University Hospital	Glostrup

Sponsors (1)

Lead Sponsor	Collaborator
Glostrup University Hospital, Copenhagen

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	pupillary constriction measured as the post-illimination pupillay response (PIPR)	The pupillary diameter 0 to 10 seconds after light stimulation, the diameter is measured relative to the initial dark adapted pupil diameter	1 day	No