Drug Drug Interaction Clinical Trial
Official title:
A Phase 1, Open Label, Fixed Sequence Study to Evaluate the Effect of BLD-0409 on the Single Dose Pharmacokinetics of a Cocktail of Probe Substrates for CYP450 Enzymes in Healthy Volunteers
A Phase 1, Open Label, Fixed Sequence Study to Evaluate the Effect of BLD-0409 on the Single Dose Pharmacokinetics of a Cocktail of Probe Substrates for CYP450 Enzymes in Healthy Volunteers
This is a single center, open label study designed to determine the effect of BLD-0409 on the PK of probe substrates and to evaluate the safety and tolerability of BLD-0409 administered alone and co-administered with a cocktail of probe substrates (i.e., Geneva cocktail less fexofenadine) in healthy adult volunteers. Geneva Cocktail (Less Fexofenadine): - CYP1A2 Caffeine 50 mg - CYP2C Flurbiprofen 10 mg - CYP2C19 Omeprazole 10 mg - CYP2D6 Dextromethorphan 10 mg - CYP3A4 Midazolam 1 mg - CYP2B6 Bupropion 20 mg ;
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