Influence of CPB and Mini CPB to the Absorption of the Metoprolol

Drug Absorption Clinical Trial

— Minimeto  

Official title:

Influence of CPB and Mini CPB to the Absorption of the Metoprolol After CABG

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01728272
• Other study ID #: KUH5101066
• Status: Recruiting
• Phase: N/A
• First received: November 13, 2012
• Last updated: August 19, 2015
• Start date: November 2012
• Est. completion date: December 2015

Study information

• Verified date: August 2015
• Source: Kuopio University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Finland: Ministry of Social Affairs and Health
• Study type: Interventional

Clinical Trial Summary

Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.

Description:

Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.

Blood samples for concentration of metoprolol are taken preoperaively, 1. and 3. day after operation, before and 10 times after intake of 50 mg metoprolol.

Sudy is randomized into 3 groups: 1. Miniperfusion n.15 2. Perfusion n.15 3. offpump n.15

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 45
• Est. completion date: December 2015
• Est. primary completion date: December 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria: elective CABG patient -

Exclusion Criteria: contraindication to metoprolol

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Drug Absorption

Intervention

Drug:
• blood concentration of metoprolol
measure blood concentration of metoprolol

Locations

Country	Name	City	State
Finland	Kuopio University Hospital	Kuopio

Sponsors (1)

Lead Sponsor	Collaborator
Kuopio University Hospital

Country where clinical trial is conducted

Finland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	recovery from rocedure	How does gereral recovery correlate between randomized groups	one year	No
Primary	absorbtion of the metoprolol	absorbtion of the metoprolol, blood samples are taken centrifuged, frozed and analyzed	one year	No
Secondary	atrial fibrillation	is there correlation of incidence of the postopeative AF and absorbtion of the metoprolol	one year	No