Influence of CPB and Mini CPB to the Absorption of the Metoprolol — Minimeto  

Drug Absorption Clinical Trial

Official title: Influence of CPB and Mini CPB to the Absorption of the Metoprolol After CABG

Status Recruiting

Clinical Trial Summary

Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.

Clinical Trial Description

Influence of perfusion, miniperfusion and off pump coronary artery bypass grafting to the absorbtion of metoprolol postoperatively, hypothesis in that miniperfusion and off pump surgery does not decrease absorbtion of the metoprolol compared to conventional pefusion.

Blood samples for concentration of metoprolol are taken preoperaively, 1. and 3. day after operation, before and 10 times after intake of 50 mg metoprolol.

Sudy is randomized into 3 groups: 1. Miniperfusion n.15 2. Perfusion n.15 3. offpump n.15 ;

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Drug Absorption

• NCT number: NCT01728272
• Study type: Interventional
• Source: Kuopio University Hospital
• Status: Recruiting
• Phase: N/A
• Start date: November 2012
• Completion date: December 2015