| Eligibility |
Inclusion Criteria:
1. Age range 18-75 years old
2. Eastern Cooperative Oncology Group performance status 0 to 2;
3. Newly diagnosed, untreated, histological confirmed diffuse large B cell lymphoma, and
Myc=40% as well as Bcl-2=50% through immunohistochemistry;
4. Measurable disease was defined as at least one lesion =1.5 cm in length-diameter and
=1.0cm in short-diameter by CT or MRI.
5. White blood cell = 3.5×109/L, absolute neutrophil count = 1.5×109/L,platelet =
80×109/L,hemoglobin = 90 g/L. If abnormal factors of peripheral blood caused by bone
marrow or spleen involvement of lymphoma, whether to enroll depends on the judgment of
researchers
6. Total bilirubin < 1.5×upper limit of normal(ULN), ALT and AST < 1.5× ULN
7. serum creatine <1.5×ULN, and creatinine clearance rate (CCR) = 40 ml/min
8. Ultrasonic cardiogram or nuclide cardiac function showed left ventricle ejection
fraction = 50%
9. Women of childbearing potential and men who are sexually active are consent to
practicing a highly effective method of birth control. Women of childbearing potential
must have a negative serum ß-hCG within 2 weeks of enrollment
10. Patients have written informed consent to participate in the study.
Exclusion Criteria:
1. Prior sever allergy to humanized or mouse derived monoclonal antibody. Unable to
receive either lenalidomide or R-CHOP background chemotherapy.
2. History of myocardial diseases, such as unstable angina pectoris, acute myocardial
infarction within 6 months of enrollment, congenital heart failure NYHA III/IV
3. Particular kind of DLBCL,such as primary mediastinal/thymic B-cell lymphoma, EBV
positive DLBCL, primary cutaneous large B lymphoma, leg type.
4. Presence of CNS involvement
5. Having surgeries = grade 2 within 3 weeks of enrollment.
6. History or now in the treatment process of other malignancies except cured basal cell
carcinoma of skin (melanoma not included), and carcinoma in-situ of uterine cervix.
7. More than grade 3 neurotoxicity within 2 two weeks of enrollment
8. Receiving any treatment for lymphoma except short use of corticosteroid (no more than
10 days)
9. History of deep vein thrombosis or pulmonary embolism within 12 months of enrollment
10. Unable or reject to receive antithrombotic treatment
11. Presence of active HBV infection (HBsAg positive and HBV-DNA= 104), HCV infection,
acquired and congenital immunodeficiency diseases include but not limited to HIV
12. Pregnant or lactating women
13. Previously received organ transplant
14. Serious uncontrolled infection
15. Having contraindications to the use of large doses of hormone, such as uncontrolled
hyperglycemia, gastric ulcer, mental disorder.
16. Severe neurol of mental illness, including dementia and epilepsy.
17. Drug abuse, medical, psychological or social conditions which may interfering with
subjects' participation in the study or evaluation of the results
18. Patients considered unsuitable to participate in the study by the researchers
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