DNA Damage Clinical Trial
Official title:
Assessment of the Cytotoxic and Genotoxic Effect of Toothpastes With Different Forms of Fluoride on the Buccal Mucosa
The remarkable therapeutic anticaries effect of fluoride is well recognized, but in recent years, toxic effects on the oral mucosa have been discussed. So far, many in vivo studies examining the genotoxic and cytotoxic effect of fluoride in human cells (lymphocytes, bone marrow, germ cells) have been carried out, but there are no studies examining the effect of fluoride on cells of the buccal mucosa. In vitro studies have shown that sodium fluoride can be toxic to fibroblasts of the oral mucosa by inhibiting protein synthesis, suppressing mitochondrial function and consequently reducing the amount of intracellular ATP. The study would include 80 participants, aged between 18 and 75. All subjects would use the same toothpaste without fluoride for the first month, and then they would be randomly divided into four groups, where three groups would receive a toothpaste with fluoride with one of the active substances (sodium fluoride, sodium monofluorophosphate, amine fluoride) for the next 60 days, while the control group would continue to use the toothpaste without fluorine. Swabs of the buccal mucosa would be taken at 0 (before the start of use) and 30, 45 and 60 days after the start of using the tested toothpastes. The aim of this research would be to examine the cytotoxic and genotoxic effect of toothpastes containing fluoride with different active substances and to compare their effect. As a measure of genotoxicity and cytotoxicity in cells, the micronucleus test will be used.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01677169 -
Effect of Noni Juice on Lipid Peroxidation-derived DNA Adducts in Heavy Smokers
|
Phase 2 | |
| Recruiting |
NCT04372914 -
Prevention of Oral DNA Damage by Black Raspberries
|
N/A | |
| Terminated |
NCT03893617 -
Brief Stresses Experimental Study
|
Phase 1 | |
| Completed |
NCT03319654 -
Impact of DNA Fragmentation in Sperm on Pregnancy Outcome After Intra-uterine Insemination in a Spontaneous Cycle
|
N/A | |
| Active, not recruiting |
NCT06204523 -
Prospective Validation of a DNA Damage Repair-Hippo Pathway Signature in Patients With Advanced Gastric Cancer
|
||
| Completed |
NCT02696811 -
The Effects of Foods on Cell Damage Study
|
N/A | |
| Completed |
NCT01461395 -
Polscope Sperm: A Non-invasive Method to Assess DNA Damage in Individual Sperm
|
N/A | |
| Recruiting |
NCT04081428 -
Using Breath, Cell Free DNA and Image Analysis to PRedIct Normal TissUe and Tumour Response During Prostate Cancer SBRT
|
||
| Not yet recruiting |
NCT05558046 -
Predictive Value of Granulosa Cell DNA Damage in the Success of Assisted Reproductive Technique
|
||
| Recruiting |
NCT04795440 -
Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDF
|
N/A | |
| Completed |
NCT05306002 -
Nutritional Intervention and DNA Damage of Patients With HBOC
|
N/A | |
| Completed |
NCT04772703 -
DNA Damage in Critically Ill COVID-19 Patients
|
||
| Completed |
NCT05111717 -
The Effect of Desfluran On Global Dna Methylation
|
||
| Recruiting |
NCT03908736 -
Thinking Zinc: a Study of Zinc Supplements on the Navajo Nation
|
N/A | |
| Completed |
NCT04721938 -
Healthy Parents - Healthy Children. Weight Loss Before Fertility Treatment
|
N/A | |
| Recruiting |
NCT03652142 -
Predictive Biomarkers for Response to Nivolumab in Head and Neck Squamous Cell Carcinoma
|
||
| Completed |
NCT00854178 -
Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery
|
Phase 4 | |
| Active, not recruiting |
NCT05277961 -
Quantification of DNA Repair Products in the Urine After Ultraviolet Radiation of the Skin
|
N/A | |
| Completed |
NCT02058082 -
Testicular Versus Ejaculated Spermatozoa for IVF/ICSI in Men With High Sperm DNA Damage
|
N/A | |
| Completed |
NCT05055154 -
Oxidative Stress and L-CBMN Cytome Assay in Obese After 3 Weeks VLCD
|
N/A |