The Effect of Desfluran On Global Dna Methylation

Status Completed

Clinical Trial Summary

The purpose of this study is to demonstrate the molecular effect of desflurane on DNA by measuring the global DNA methylation level in patients under going lumbar spinal stenosis surgery under general anesthesia.

Clinical Trial Description

Forty patients scheduled for lumbar spinal surgery will include in the study. Peripheral venous blood samples will collect prior to the induction of anesthesia (T1) and after 120 minutes (T2). Anesthesia will maintaine with 40%-60% O2-air mixture and 6% desflurane. DNA will obtain from blood samples with the help of DNA isolation kit and global DNA methylation analysis will perform by ELISA method. ;

Study Design

Related Conditions & MeSH terms

DNA Damage

Clinical Trial Details

NCT number	NCT05111717
Study type	Observational
Source	Mugla Sitki Koçman University
Contact
Status	Completed
Phase
Start date	November 17, 2021
Completion date	December 30, 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT01677169` - Effect of Noni Juice on Lipid Peroxidation-derived DNA Adducts in Heavy Smokers	Phase 2
Recruiting	`NCT04372914` - Prevention of Oral DNA Damage by Black Raspberries	N/A
Terminated	`NCT03893617` - Brief Stresses Experimental Study	Phase 1
Completed	`NCT03319654` - Impact of DNA Fragmentation in Sperm on Pregnancy Outcome After Intra-uterine Insemination in a Spontaneous Cycle	N/A
Active, not recruiting	`NCT06204523` - Prospective Validation of a DNA Damage Repair-Hippo Pathway Signature in Patients With Advanced Gastric Cancer
Completed	`NCT02696811` - The Effects of Foods on Cell Damage Study	N/A
Completed	`NCT01461395` - Polscope Sperm: A Non-invasive Method to Assess DNA Damage in Individual Sperm	N/A
Recruiting	`NCT04081428` - Using Breath, Cell Free DNA and Image Analysis to PRedIct Normal TissUe and Tumour Response During Prostate Cancer SBRT
Not yet recruiting	`NCT05558046` - Predictive Value of Granulosa Cell DNA Damage in the Success of Assisted Reproductive Technique
Recruiting	`NCT04795440` - Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDF	N/A
Completed	`NCT05306002` - Nutritional Intervention and DNA Damage of Patients With HBOC	N/A
Completed	`NCT04772703` - DNA Damage in Critically Ill COVID-19 Patients
Recruiting	`NCT05596149` - Assessment of the Cytotoxic and Genotoxic Effect of Toothpastes With Different Forms of Fluoride on the Buccal Mucosa	N/A
Recruiting	`NCT03908736` - Thinking Zinc: a Study of Zinc Supplements on the Navajo Nation	N/A
Completed	`NCT04721938` - Healthy Parents - Healthy Children. Weight Loss Before Fertility Treatment	N/A
Recruiting	`NCT03652142` - Predictive Biomarkers for Response to Nivolumab in Head and Neck Squamous Cell Carcinoma
Completed	`NCT00854178` - Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery	Phase 4
Active, not recruiting	`NCT05277961` - Quantification of DNA Repair Products in the Urine After Ultraviolet Radiation of the Skin	N/A
Completed	`NCT02058082` - Testicular Versus Ejaculated Spermatozoa for IVF/ICSI in Men With High Sperm DNA Damage	N/A
Completed	`NCT05007171` - Changes in Anthropometric, Biochemical and DNA Damage Parameters After 3-weeks VLCD in Severely Obese Patients	N/A