DNA Damage Clinical Trial
Official title:
In Vivo Assessment of Geno- and Cytotoxicity of Fluoridated Toothpastes and Mouthrinses on Human Buccal Epithelial Cells
Buccal cells represent the first barrier to the oral hygiene products' potential toxic effect. The usual concentration of fluoride in toothpastes is 1000/1100 parts per million (ppm F); toothpastes with higher (1500 ppm F) and lower than conventional fluoride levels (around 500 ppm F) are available in many countries. Toothpastes containing higher concentrations of fluoride confer greater protection against caries but at the same time the fluoride is able to induce harmful effects on oral mucosa cells. The study would include around 40 participants, aged between 20 and 65, divided in two groups. Each group will use fluoride free toothpaste for 28 days, than afterwards group B will get toothpastes (each for 28 days) with no fluoride, 1045 ppm F and 1450 ppm F used together with mouthrinse containing 450 ppm F, while the group A will have everything the same except the mouthrinse that will contain no fluoride - a placebo mouthrinse. Every 28 days buccal cells samples would be collected from each participant and a Buccal micronucleus cytome assay would be performed according to Nature protocols: Thomas et all. The aim of this study would be to assess the possible cumulative effect of together use of fluoridated toothpastes and mouthrinses, since population worldwide uses them together without any exact studies about toxicity.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT01677169 -
Effect of Noni Juice on Lipid Peroxidation-derived DNA Adducts in Heavy Smokers
|
Phase 2 | |
Recruiting |
NCT04372914 -
Prevention of Oral DNA Damage by Black Raspberries
|
N/A | |
Completed |
NCT03319654 -
Impact of DNA Fragmentation in Sperm on Pregnancy Outcome After Intra-uterine Insemination in a Spontaneous Cycle
|
N/A | |
Terminated |
NCT03893617 -
Brief Stresses Experimental Study
|
Phase 1 | |
Active, not recruiting |
NCT06204523 -
Prospective Validation of a DNA Damage Repair-Hippo Pathway Signature in Patients With Advanced Gastric Cancer
|
||
Completed |
NCT02696811 -
The Effects of Foods on Cell Damage Study
|
N/A | |
Completed |
NCT01461395 -
Polscope Sperm: A Non-invasive Method to Assess DNA Damage in Individual Sperm
|
N/A | |
Recruiting |
NCT04081428 -
Using Breath, Cell Free DNA and Image Analysis to PRedIct Normal TissUe and Tumour Response During Prostate Cancer SBRT
|
||
Not yet recruiting |
NCT05558046 -
Predictive Value of Granulosa Cell DNA Damage in the Success of Assisted Reproductive Technique
|
||
Recruiting |
NCT04795440 -
Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDF
|
N/A | |
Completed |
NCT05306002 -
Nutritional Intervention and DNA Damage of Patients With HBOC
|
N/A | |
Completed |
NCT04772703 -
DNA Damage in Critically Ill COVID-19 Patients
|
||
Completed |
NCT05111717 -
The Effect of Desfluran On Global Dna Methylation
|
||
Recruiting |
NCT05596149 -
Assessment of the Cytotoxic and Genotoxic Effect of Toothpastes With Different Forms of Fluoride on the Buccal Mucosa
|
N/A | |
Recruiting |
NCT03908736 -
Thinking Zinc: a Study of Zinc Supplements on the Navajo Nation
|
N/A | |
Completed |
NCT04721938 -
Healthy Parents - Healthy Children. Weight Loss Before Fertility Treatment
|
N/A | |
Recruiting |
NCT03652142 -
Predictive Biomarkers for Response to Nivolumab in Head and Neck Squamous Cell Carcinoma
|
||
Completed |
NCT00854178 -
Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery
|
Phase 4 | |
Active, not recruiting |
NCT05277961 -
Quantification of DNA Repair Products in the Urine After Ultraviolet Radiation of the Skin
|
N/A | |
Completed |
NCT02058082 -
Testicular Versus Ejaculated Spermatozoa for IVF/ICSI in Men With High Sperm DNA Damage
|
N/A |