DNA Damage Clinical Trial
Official title:
Toxicogenomic and Immunocytotoxic Effects of Propofol and Isoflurane Anesthetics in Patients Undergoing Elective Surgery
The purpose of this study is to evaluate if the anesthetics propofol and isoflurane can damage DNA, induce apoptosis, change expression of genes related to apoptosis and DNA repair and change cytokines profile in patients submitted to elective surgery.
Status | Completed |
Enrollment | 26 |
Est. completion date | December 2009 |
Est. primary completion date | December 2009 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 50 Years |
Eligibility |
Inclusion Criteria: - patients in good health American Society of Anesthesia status physical I - elective minor surgery - general anesthesia Exclusion Criteria: - smokers - alcoholics - previous medication or radiation |
Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Supportive Care
Country | Name | City | State |
---|---|---|---|
Brazil | Botucatu Medical School, UNESP | Botucatu | São Paulo |
Lead Sponsor | Collaborator |
---|---|
UPECLIN HC FM Botucatu Unesp | Fundação de Amparo à Pesquisa do Estado de São Paulo |
Brazil,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Evaluation of genotoxicity, gene expression, apoptosis and cytokines profile | within 1 day after surgery | Yes |
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