Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00854178
Other study ID # upeclin/HC/FMB-Unesp-20
Secondary ID
Status Completed
Phase Phase 4
First received March 2, 2009
Last updated January 5, 2010
Start date March 2008
Est. completion date December 2009

Study information

Verified date January 2010
Source UPECLIN HC FM Botucatu Unesp
Contact n/a
Is FDA regulated No
Health authority Brazil: National Committee of Ethics in Research
Study type Interventional

Clinical Trial Summary

The purpose of this study is to evaluate if the anesthetics propofol and isoflurane can damage DNA, induce apoptosis, change expression of genes related to apoptosis and DNA repair and change cytokines profile in patients submitted to elective surgery.


Description:

It is expected that the results provide relevant information to understand the possible adverse effects of anesthetics and contribute to the establishment of strategies aimed at reducing the risks to exposed individuals.


Recruitment information / eligibility

Status Completed
Enrollment 26
Est. completion date December 2009
Est. primary completion date December 2009
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 50 Years
Eligibility Inclusion Criteria:

- patients in good health American Society of Anesthesia status physical I

- elective minor surgery

- general anesthesia

Exclusion Criteria:

- smokers

- alcoholics

- previous medication or radiation

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Supportive Care


Intervention

Drug:
Comparison of two anesthetic drugs
Isoflurane 1,0 minimum alveolar concentration Propofol 2mg/kg and 4ug/ml

Locations

Country Name City State
Brazil Botucatu Medical School, UNESP Botucatu São Paulo

Sponsors (2)

Lead Sponsor Collaborator
UPECLIN HC FM Botucatu Unesp Fundação de Amparo à Pesquisa do Estado de São Paulo

Country where clinical trial is conducted

Brazil, 

Outcome

Type Measure Description Time frame Safety issue
Primary Evaluation of genotoxicity, gene expression, apoptosis and cytokines profile within 1 day after surgery Yes
See also
  Status Clinical Trial Phase
Completed NCT01677169 - Effect of Noni Juice on Lipid Peroxidation-derived DNA Adducts in Heavy Smokers Phase 2
Recruiting NCT04372914 - Prevention of Oral DNA Damage by Black Raspberries N/A
Terminated NCT03893617 - Brief Stresses Experimental Study Phase 1
Completed NCT03319654 - Impact of DNA Fragmentation in Sperm on Pregnancy Outcome After Intra-uterine Insemination in a Spontaneous Cycle N/A
Active, not recruiting NCT06204523 - Prospective Validation of a DNA Damage Repair-Hippo Pathway Signature in Patients With Advanced Gastric Cancer
Completed NCT02696811 - The Effects of Foods on Cell Damage Study N/A
Completed NCT01461395 - Polscope Sperm: A Non-invasive Method to Assess DNA Damage in Individual Sperm N/A
Recruiting NCT04081428 - Using Breath, Cell Free DNA and Image Analysis to PRedIct Normal TissUe and Tumour Response During Prostate Cancer SBRT
Not yet recruiting NCT05558046 - Predictive Value of Granulosa Cell DNA Damage in the Success of Assisted Reproductive Technique
Recruiting NCT04795440 - Comparison of ICSI Outcomes in Cycles Using Testicular and Ejaculate Sperm From Couples With High SDF N/A
Completed NCT05306002 - Nutritional Intervention and DNA Damage of Patients With HBOC N/A
Completed NCT04772703 - DNA Damage in Critically Ill COVID-19 Patients
Completed NCT05111717 - The Effect of Desfluran On Global Dna Methylation
Recruiting NCT05596149 - Assessment of the Cytotoxic and Genotoxic Effect of Toothpastes With Different Forms of Fluoride on the Buccal Mucosa N/A
Recruiting NCT03908736 - Thinking Zinc: a Study of Zinc Supplements on the Navajo Nation N/A
Completed NCT04721938 - Healthy Parents - Healthy Children. Weight Loss Before Fertility Treatment N/A
Recruiting NCT03652142 - Predictive Biomarkers for Response to Nivolumab in Head and Neck Squamous Cell Carcinoma
Active, not recruiting NCT05277961 - Quantification of DNA Repair Products in the Urine After Ultraviolet Radiation of the Skin N/A
Completed NCT02058082 - Testicular Versus Ejaculated Spermatozoa for IVF/ICSI in Men With High Sperm DNA Damage N/A
Completed NCT05007171 - Changes in Anthropometric, Biochemical and DNA Damage Parameters After 3-weeks VLCD in Severely Obese Patients N/A