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Clinical Trial Summary

The purpose of this study is to determine whether treatment with IBI110 single agent and in combination with sintilimab demonstrates sufficient efficacy/safety in r/r DLBCL.

Clinical Trial Description

This is a phase Ib, open-label, randomized study to determine the efficacy and safety of treatment with IBI110 single agent and in combination with sintilimab in DLBCL that are relapsed and/or refractory to available standard of care therapies. Participants in each cohort are randomly assigned to one of the two arms: IBI110 single agent arm and IBI110 in combination with sintilimab arm. Participants received study treatment for a maximum of 2 years, or until disease progression (assessed by investigator per Lugano 2014 Criteria for Malignant Lymphoma (Cheson et al 2014)), unacceptable toxicity, death or discontinuation from study treatment for any other reason. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05039658
Study type Interventional
Source Innovent Biologics (Suzhou) Co. Ltd.
Contact yong wang
Phone 0512-69566088
Email [email protected]
Status Not yet recruiting
Phase Phase 1
Start date September 27, 2021
Completion date December 2, 2022

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