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Rifaximin Delayed Release for the Prevention of Recurrent Acute Diverticulitis and Diverticular Complications. — ROAD  

Diverticulitis Clinical Trial

Official title:
Rifaximin Delayed Release (400 mg Tablet) for the Prevention of Recurrent Acute Diverticulitis and Diverticular Complications. A Phase II, Multicenter, Double-blind, Placebo-controlled, Randomized Clinical Trial

Clinical Trial Summary

Colonic microbiota changes may play a key role in the pathogenesis of acute diverticulitis. A previous proof-of-concept study suggests that rifaximin, a low-absorbable oral antibiotic, may be beneficial for prevention of acute diverticulitis recurrence by modulating the gut microflora. The main objective of this study is to evaluate the safety and efficacy of two different doses of a delayed release formulation of rifaximin, versus placebo, for the prevention of recurrence of acute diverticulitis and diverticular complications in patients with a recent episode of acute diverticulitis.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03469050
Study type Interventional
Source Alfasigma S.p.A.
Contact
Status Terminated
Phase Phase 2/Phase 3
Start date July 2, 2018
Completion date December 22, 2020
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