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Dissociative Disorders clinical trials

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NCT ID: NCT04631003 Recruiting - Clinical trials for Scapholunate Dissociation

Intraoperativ Testing of Scapholunate Instability in Radius Fracture

ScaLu
Start date: October 1, 2020
Phase: N/A
Study type: Interventional

Ligamental side injuries in distal radius fractures are not uncommon, but diagnosis is often difficult. Diagnosis with the simultaneous presence of a fracture is not very reliable and usually highly subjective. 5-64% of radius fractures are accompanied by injuries of the scapholunary ligament (SL). Intra-articular radius fractures have a significantly higher prevalence for SL dissociation, due to a greater energy transfer to the hand roots. In 5-10% of cases, distal, intra-articular radius fractures are associated with complete ruptures of the dorsal scapholunary band. The number of untreated SL band lesions in distal radius fractures is largely unknown. If left untreated, scapholunary ligament lesions, with the simultaneous presence of a rupture of the dorsal ligament, (DIC) can lead to symptomatic carpal instability, therefore the correct diagnosis and adequate therapy is necessary even in the presence of a distal radius fracture. Through the band ruptures, both the Os lunatum and the Os scaphoideum experience irregular motion. This leads to Dorsal Intercalated Segment Instability (DISI) and is reflected by the flexion of the os scaphoideum and the extension of the os lunatum radiologically in the lateral uptake with an increase of the scapholunary angle > 60° (usually maximum 45)° and the radioscaphoidal angle >15°. An incorrect use can lead to the development of SLAC-wrist (Scapho-Lunate Advanced Collapse) over years, this risk should be reduced if possibel by recognizing the original injury. With regard to this problem, we would like to establish a radiological, dynamic functional test, allowing scapholunary ligament lesions in distal radius fractures to be diagnosed intraoperatively.

NCT ID: NCT04580147 Recruiting - Clinical trials for Proliferative Vitreoretinopathy

Intravitreal Aflibercept for the Prevention of Proliferative Vitreoretinopathy Following Retinal Detachment Repair

PREVENT-PVR
Start date: October 15, 2020
Phase: Phase 2
Study type: Interventional

The primary objective of the study is to determine if serial intravitreal aflibercept injections (IAI) improve the single surgery anatomic success rate following surgical repair of primary, macula involving rhegmatogenous retinal detachment (RRD) deemed at high risk for proliferative vitreoretinopathy (PVR). Preclinical work has revealed that competitive inhibition of platelet derived growth factor (PDGF) by vascular endothelial growth factor (VEGF) potentiates a pathologic, sustained activation of PDGF receptors that is critical to the progression of experimental PVR. VEGF blockade would mitigate this pathologic activation.

NCT ID: NCT04571788 Recruiting - Surgery Clinical Trials

Treating Rhegmatogenous Retinal Detachment by Foldable Capsular Buckle

Start date: September 1, 2019
Phase:
Study type: Observational [Patient Registry]

To evaluate the efficacy and safety of treating rhegmatogenous retinal detachment (RRD) using foldable capsular buckle (FCB). It is a multi-center clinical ,randomized, controlled, and single-blind clinical study.

NCT ID: NCT04557527 Recruiting - Clinical trials for Retinal Detachment With Break

Suprachoroidal Visco-buckling for the Treatment of Rhegmatogenous Retinal Detachment

VIKING
Start date: February 7, 2022
Phase: N/A
Study type: Interventional

The study compares standard surgery for retinal detachment (RD) (vitrectomy, cryotherapy and gas) with a surgical variation that replaces the intraocular gas tamponade with suprachoroidal injection of viscoelastic underneath the break that caused the retinal detachment.

NCT ID: NCT04518696 Not yet recruiting - Retinal Detachment Clinical Trials

Suprachoroidal Buckling for the Management of Rhegmatogenous Retinal Detachment

Start date: September 1, 2020
Phase: N/A
Study type: Interventional

Study of novel surgical technic-suprachoroidal buckling for therapy of rhegmatogenous retinal detachment.It was excpted to reattached the retina and improve visual function of rhegmatogenous retinal detachment patients.

NCT ID: NCT04464629 Terminated - Retinal Detachment Clinical Trials

Assessing the Efficacy and Safety of DEXTENZA in Pseudo Phakic Patients Undergoing Gas Bubble Repair and Laser Following Retinal Detachment

Start date: July 14, 2020
Phase: Phase 4
Study type: Interventional

This prospective, open-label, single-center, randomized, investigator-sponsored clinical study seeks to investigate: how will pseudophakic patients respond in terms of objective and subjective outcomes, when treated with Dextenza compared to topical prednisolone acetate following gas bubble repair and laser for RD.

NCT ID: NCT04346095 Not yet recruiting - Retinal Detachment Clinical Trials

Oral Sedation in Vitreoretinal Surgery

Start date: June 2020
Phase: Phase 4
Study type: Interventional

The purpose of this study is to compare the efficacy of oral sedation to intravenous sedation with anesthesiology support and monitoring.

NCT ID: NCT04168255 Completed - Retinal Detachment Clinical Trials

Double Retinal Tamponade for Retinal Detachment With PVR and Inferior Breaks.

IRB
Start date: October 1, 2017
Phase: N/A
Study type: Interventional

Purpose To evaluate the efficacy of perfluorocarbone liquids (PFCLs) for tamponading lower retinal breaks to achieve retinal reattachment in eyes of retinal detachment with proliferative vitreoretinopathy (PVR) and inferior breaks. Patients and methods The study was prospective non comparative interventional study. It included thirty eyes of 30 patients suffering from retinal detachment with proliferative vitreoretinopathy and inferior breaks attending the ophthalmology department at Minia University Hospital. The mean age was 50.2± 10.63 years, 18 females and 12 males. Double retinal tamponade procedure were done and the patients were followed for one year. The primary outcome was to achieve successful retinal reattachment and the secondary outcome is to achieve improvement in the postoperative visual acuity.

NCT ID: NCT04158622 Recruiting - Retinal Detachment Clinical Trials

Retinal Displacement Rates in Pneumatic Retinopexy Versus Pars Plana Vitrectomy For Primary Retinal Detachment

REVEAL
Start date: March 15, 2021
Phase: N/A
Study type: Interventional

Patients may experience metamorphopsia, or image distortion, after having vitrectomy to repair their rhegmatogenous retinal detachments (RRDs) especially those with a detached macula. Retinal displacement, as measured on autofluorescence photography, likely contributes to this distortion. There is no study in the scientific literature comparing the rate of retinal displacement and its association with visual function, including metamorphopsia, in patients undergoing different procedures for RRD repair. Based on the recently published PIVOT trial, patients who underwent Pneumatic Retinopexy (PnR) had less vertical distortion at 12 months than patients who had Pars Plana Vitrectomy (PPV). It is hypothesized that PnR will cause less retinal displacement than PPV for patients with macula-off primary retinal detachment.

NCT ID: NCT04139746 Completed - Retina Detachment Clinical Trials

Pneumatic Retinopexy for Severe Bullous Retinal Detachment

Start date: March 1, 2017
Phase: N/A
Study type: Interventional

To compare the efficacy and safety outcomes of scleral buckling (SB) and drainage-injection-pneumoretinopexy (DIP), a modified pneumatic retinopexy technique, in which, before injecting the gas, the drainage of the subretinal fluid is performed with a simultaneous injection of balanced salt solution (BSS) in the vitreous chamber, for the treatment of severe superior bullous rhegmatogenous retinal detachment (SBRD).