Posttraumatic Stress Disorder Clinical Trial
Official title:
Stabilizing Group Treatment of Complex Trauma: A Randomized Controlled Trial
The research project outlined in this proposal aims to investigate the effectiveness of stabilizing group treatment as an add-on to conventional treatment, for patients with Post Traumatic Stress Disorder (PTSD) or dissociative disorders after childhood abuse. The investigators also aim to study psychophysiological markers associated with complex trauma and treatment, mechanisms of change involved in treatment, and which patient characteristics that predict positive outcome.
Patients with histories of repeated traumatization in childhood often display a wide array of
symptoms described as complex traumatic stress disorder. This sequela involves a high degree
of comorbid mental and somatic disturbances, and entails tremendous health care costs for
society and suffering for the victims. Despite the prevalence and consequences of complex
trauma, research on effective treatments is extremely limited. Expert clinicians suggest that
initial treatment for these patients should focus on stabilization of symptoms through
psychoeducation and skills - training, and some research has supported this advice. Offering
such treatment as group therapy can be both cost - effective and give patients additional
peer-support. The research project outlined in this proposal aims to investigate the
effectiveness of stabilizing group treatment as an add-on to conventional treatment, for
patients with PTSD or dissociative disorders after childhood abuse. This will be investigated
in a randomized controlled design. The investigators also aim to discover psychophysiological
markers associated with treatment, mechanisms of change involved in treatment, and what
patient characteristics that predict outcome. The results may contribute to new knowledge
about treatment of complex traumatization, as well as new and improved health services for a
vulnerable patient group with little specialized treatment today.
The main aim of this project is to compare the effectiveness of stabilizing group treatment
as an add-on to conventional individual therapy, to conventional individual therapy alone, in
a randomized controlled design. This will be tested in two independent diagnostic groups:
Patients with PTSD and patients with Dissociative disorders, both groups with reports of
childhood abuse. The investigators will further investigate how level of dissociative
symptoms influence treatment, how group climate influence symptoms, the relationship between
individual and group therapy in combined treatment, and how treatment affects Heart Rate
Variability. The investigators also seek to evaluate the treatment economically with a
societal perspective, carrying out cost-utility analyses.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03384706 -
A Comparison of CPT Versus ART Versus WL
|
N/A | |
| Completed |
NCT03418129 -
Neuromodulatory Treatments for Pain Management in TBI
|
N/A | |
| Completed |
NCT03129204 -
Sensation Awareness Focused Training for Spouses
|
N/A | |
| Recruiting |
NCT05651295 -
A Precision Medicine Approach to Target Engagement for Emotion Regulation
|
N/A | |
| Completed |
NCT05113277 -
Development and Evaluation of a Tonic Immobility Focused Psychoeducational Intervention
|
N/A | |
| Recruiting |
NCT05327504 -
Written Exposure Therapy for Veterans With SUD and PTSD
|
N/A | |
| Recruiting |
NCT05843695 -
Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety
|
N/A | |
| Active, not recruiting |
NCT05530642 -
An Augmented Training Program for Preventing Post-Traumatic Stress Injuries Among Diverse Public Safety Personnel
|
N/A | |
| Completed |
NCT00644423 -
Omega-3 Fatty Acids and Post Traumatic Stress Disorder (PTSD)
|
N/A | |
| Completed |
NCT02989987 -
NET for SGBV Survivors in Eastern DR Congo
|
N/A | |
| Completed |
NCT02320799 -
Randomized Controlled Trial of Interpersonal Psychotherapy for Depression and PTSD Among HIV+ Women in Kenya
|
N/A | |
| Recruiting |
NCT02293291 -
Thermal Clinic Treatment in Gulf War Illness
|
Phase 1/Phase 2 | |
| Completed |
NCT02242136 -
Treatment of Posttraumatic Stress Disorder and Aggressive Behavior in Soldiers and Ex-combatants
|
N/A | |
| Completed |
NCT01911585 -
Efficacy of 60-minute Versus 90-minute Sessions in Treating PTSD Using Prolonged Exposure
|
N/A | |
| Completed |
NCT02720497 -
The Efficacy of 90-Minute Versus 60-Minute Sessions of Prolonged Exposure for PTSD
|
N/A | |
| Completed |
NCT01693978 -
Contingency Outcomes in Prolonged Exposure
|
N/A | |
| Terminated |
NCT01408641 -
Topiramate for Alcohol Use in Posttraumatic Stress Disorder
|
N/A | |
| Completed |
NCT01469754 -
Longitudinal Survey Analysis in Lymphoma Survivors
|
N/A | |
| Completed |
NCT02362477 -
Telemental Health and Cognitive Processing Therapy for Female Veterans With Military-related PTSD
|
Phase 3 | |
| Terminated |
NCT01239173 -
Emotional Memory Reactivation in Posttraumatic Stress Disorder
|
Phase 3 |