Disorder of Urinary Stent Clinical Trial
Official title:
Phase One of Study on Urinary Stent Complications and Treatment
The aim of the investigators study is to evaluate whether alpha-blockers such as terazosin and anti-cholinergics such as tolterodine can be relieve the DJ-stent related symptoms.
Ureteral stent (US) has been as essential tool in the urologist's surgeries and is useful
instruments that its indications increase due to new stent technologies and improvement of
patient's comfort.
US associated with discomfort complications that include lower urinary tract symptoms (LUTS)
as frequency, urgency, dysuria, incomplete emptying, flanks and suprapubic's pain,
incontinence, hematuria, movement of stent, infection and encrustation of stent. US related
symptoms are as same as LUTS due to benign prostate hyperplasia and overactive bladder which
relieve with alpha-blockers and anticholinergic. The purpose of our study is to investigate
the effect of terazosin and tolterodine lonely and together in comparison of placebo on US
related symptoms.
The investigators study will be done prospectively. The patients who underwent indwelling
Double-j stent distributed into four groups: 1)receive placebo 2)receive terazosin 2mg twice
3)receive tolterodine 2mg daily 4) receive terazosin 2mg twice and tolterodine 2mg daily.
All of the patients receive prophylactic antibiotic and on demand analgesic. After entrance
to study, they fulfill the International Prostatic Symptoms Score (IPSS) and Visual Analog
Scale (VAS) on the before indwelling US, two weeks after indwelling US and US removal time,
then the investigators will evaluate the drug's effect on US related symptoms.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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