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COgnitive and Physical Exercise to Improve Outcomes After Surgery (COPE-iOS) Study — COPEiOS  

Surgery Clinical Trial

Official title:
COgnitive and Physical Exercise to Improve Outcomes After Surgery (COPE-iOS) Study

Clinical Trial Summary

The COgnitive and Physical Exercise to improve Outcomes after Surgery (COPE-iOS) study is testing the hypothesis that a pragmatic program combining computerized cognitive training and physical training throughout the perioperative period will improve long-term cognitive and disability outcomes in older surgical patients at high risk for decline. To accomplish these goals, the Investigators are randomizing 250 patients ≥60 years old undergoing elective major non-cardiac surgery with expected hospitalization ≥3 days to a pragmatic comprehensive training program (computerized cognitive training and supervised progressive physical exercise) or to active control (control computer game, stretching exercises) for 2-4 weeks prior to surgery and for 3 months after discharge. At baseline and after discharge, the Investigators will assess global cognition, activities of daily living, depression, endothelial and blood brain barrier function (blood biomarkers), and neuroimaging (anatomical and functional MRI). In this early stage trial, the Investigators will determine if certain subgroups benefit most, program aspects with greatest effect on outcomes, mechanistic associations with outcomes, and additional exploratory analyses.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04889417
Study type Interventional
Source Vanderbilt University Medical Center
Contact Christopher G Hughes, MD
Phone 16153436268
Email christopher.hughes@vumc.org
Status Recruiting
Phase N/A
Start date October 12, 2021
Completion date July 1, 2027
View Details
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