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Digestive System Fistula clinical trials

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NCT ID: NCT05051358 Enrolling by invitation - Clinical trials for Gastrointestinal Cancer

Therapeutic Endoscopic Ultrasound for Gastrointestinal Disorders: A Multicenter Registry Study

TEUS Registry
Start date: February 11, 2021
Phase:
Study type: Observational

The purpose of this retrospective chart-review registry study is to evaluate the safety profile, efficacy profile and cost-effectiveness of the various therapeutic endoscopic ultrasound (EUS) procedures (for benign and malignant gastrointestinal disorders). 1. To assess the clinical and technical success rates of EUS-Guided interventions 2. To document the impact of therapeutic EUS procedures on the management of gastrointestinal disorders including malignancies through cost effective analyses. 3. Compare endoscopic interventions to non-endoscopic interventions for the same clinical indications and evaluate safety and efficacy.

NCT ID: NCT04670276 Recruiting - Clinical trials for Gastrointestinal Fistula

Conservative Treatment of Gastrointestinal Fistulas by Endoscopic Injection of tSVFem

tSVFem
Start date: November 2, 2020
Phase: N/A
Study type: Interventional

Gastrointestinal (GI) fistula is a complex condition with high mortality and requiring a multidisciplinary management. The aim of this study is to exploit the regenerative-tissue capacities of autologous emulsified adipose tissue-derived stromal vascular fraction (tSVFem, widely used in other medical fields - like plastic surgery -for different purposes) harvested and delivered locally by endoscopy to close the GI fistula. The proposed technique for the treatment of GI fistulas with tSVFem requires a minimal, inexpensive, easily reproducible mechanical manipulation of autologous adipose tissue without necessity of any enzymatic digestion or cell expansion.

NCT ID: NCT04180735 Completed - Clinical trials for Liver Transplantation

Intestinal Perforation in Patients Receiving an Orthtopic Liver Transplantation in the Montpellier University Hospital

Perfogreffe
Start date: September 30, 2019
Phase:
Study type: Observational

Liver transplantation enhances the prognosis of patients with cirrhoses or hepatocellular carcinoma. However some patients develop intestinal perforations for which the prognosis is poor. The aim of the study is to evaluate the risk factors of intestinal perforations using a retrospective study scheme.

NCT ID: NCT03742752 Terminated - Clinical trials for Gastrointestinal Fistula

Enteral Versus Parenteral Nutrition in the Conservative Treatment of Upper Gastrointestinal Fistula After Surgery

NUTRILEAK
Start date: June 7, 2019
Phase: N/A
Study type: Interventional

The incidence of clinically significant anastomotic leaks (AL) after upper gastrointestinal (GI) surgery is approximately 4 % - 20 %, and the associated mortality can be as high as 80 % . Nutritional support is a key component of therapy in such cases, related to high prevalence of malnutrition and nil per month required for leak treatment. In the prophylactic setting, before the occurrence of any AL, a literature review based on seven randomised trials showed that enteral nutrition (EN) is associated with shorter hospital stay, lower incidence of severe of infectious complications, lower severity of complications and decreased cost compared to parenteral nutrition (TPN) following major upper GI surgery . In the curative setting, after the AL occurrence, very few evidence is available. Only one randomized clinical trial suggested the superiority of EN versus TPN after pancreatic surgery with a increase of the 30-day fistula closure rate from 37% in the TPN group to 60% in the EN group . This sole randomised study available did not include all postoperative upper GI AL (PUGIAL) that can occur after esophageal, gastric, duodenal, pancreatic surgery (including obesity surgery), whereas the concept of enteral nutritional support is highly relevant for all these situations. However surgeons are usually reluctant to provide EN in case of AL. A randomized study suggested the feasibility of EN in 47 patients with upper GI AL but no randomized study to date has been designed to test the superiority of EN versus TPN in PUGIAL. The study aim is to demonstrate the superiority of EN versus TPN to accelerate AL healing after upper GI surgery. Hypothesis: EN increases the 30-day fistula closure rate in PUGIAL, allowing better HRQOL without increasing morbi-mortality.

NCT ID: NCT02038504 Completed - Clinical trials for Gastrointestinal Fistula

Investigating the Role of EN in NTIS Among Fistula Patients

EN;NTIS
Start date: January 2013
Phase: N/A
Study type: Observational

The purpose of this study is to investigate whether enteral nutrition are effective in the treatment of nonthyroidal illness syndrome among fistula patients.

NCT ID: NCT01828892 Recruiting - Clinical trials for Low-output External Gastrointestinal Fistula

Glue Application in the Treatment of Low-Output Fistulas

FG-treatment
Start date: March 2014
Phase: N/A
Study type: Interventional

Adjuvant use of fibrin glue (FG) in the fistula tract has been shown to promote closure of low-output enterocutaneous fistulas (ECFs). The primary objectives of this study are to compare the clinical efficacy, safety of autologous platelet-rich fibrin glue (PRFG), commercial fibrin glue, and control therapy in the management of patients with low-output volume ECFs.

NCT ID: NCT01672593 Recruiting - Clinical trials for Low-output External Gastrointestinal Fistula

Glue Sealing for Patients With Low-Output ECFs

Glue-sealing
Start date: May 2012
Phase: N/A
Study type: Interventional

Adjuvant use of fibrin glue (FG) in the fistula tract has been shown to promote closure of low-output ECFs. The primary objectives of this study are to compare the clinical efficacy, safety of autologous platelet-rich fibrin glue (PRFG) and a commercially available fibrin sealant Bioseal® in the management of patients with low-output volume ECFs.

NCT ID: NCT01568853 Completed - Severe Sepsis Clinical Trials

A Prospective Study of The Complement Depletion in Patients With Severe Abdominal Sepsis

Start date: November 2011
Phase: N/A
Study type: Interventional

The role of complement system in bridging innate and adaptive immunity has been confirmed in various invasive pathogens. The aim of this study is to investigate the alteration of complement C3 in patients with severe abdominal sepsis and evaluate the role of complement C3 depletion in prognosis of such patients. The relationship between complement C3 depletion and adaptive immunity is studied meanwhile.

NCT ID: NCT01303653 Recruiting - Clinical trials for Gastrointestinal Fistula

Endoscopic Treatment of Intestinal Fistulas and Perforations

Start date: October 2010
Phase: Phase 1
Study type: Interventional

Gastrointestinal leaks or perforations are currently treated through either open or laparoscopic surgical procedures. The purpose of this research is to determine whether new endoscopic tools are safe and effective in the treatment of such conditions and can overcome the need of invasive surgical procedures.