Diffusion Tensor Imaging Clinical Trial
— LiNPHOfficial title:
Advanced MR-methods, Protein Levels in Cerebrospinal Fluid, Gait Analysis and Symptoms in Patients With Idiopathic Normal Pressure Hydrocephalus.
LiNPH is a prospective single center clinical and radiological study.
Status | Recruiting |
Enrollment | 50 |
Est. completion date | September 30, 2024 |
Est. primary completion date | September 30, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion Criteria: Patients fulfilling the clinical and radiological criteria for a possible or probable iNPH diagnosis, according to the American-European Guidelines from 2005. - Exclusion Criteria: Patients unable to understand instructions with an MMSE lower than 17, claustrophobia or implant which makes the participation in MRI studies unable. - |
Country | Name | City | State |
---|---|---|---|
Sweden | University Hospital of Linköping | Linköping |
Lead Sponsor | Collaborator |
---|---|
Linkoeping University |
Sweden,
Ege S. [Management of urinary incontinence in a geriatric rehabilitation department : Global urinary incontinence assessment incorporating the International Consultation on Incontinence Questionnare - Urinary Incontinence Short Form (ICIQ-UI SF)]. Z Gerontol Geriatr. 2018 Apr;51(3):301-313. doi: 10.1007/s00391-016-1173-3. Epub 2017 Feb 8. German. — View Citation
Eleftheriou A, Blystad I, Tisell A, Gasslander J, Lundin F. Publisher Correction: Indication of Thalamo-Cortical Circuit Dysfunction in Idiopathic Normal Pressure Hydrocephalus: A Diffusion Tensor Imaging Study. Sci Rep. 2020 Jul 16;10(1):12014. doi: 10.1038/s41598-020-69149-x. — View Citation
Ishikawa M, Hashimoto M, Kuwana N, Mori E, Miyake H, Wachi A, Takeuchi T, Kazui H, Koyama H. Guidelines for management of idiopathic normal pressure hydrocephalus. Neurol Med Chir (Tokyo). 2008;48 Suppl:S1-23. doi: 10.2176/nmc.48.s1. — View Citation
Keong NC, Pena A, Price SJ, Czosnyka M, Czosnyka Z, DeVito EE, Housden CR, Sahakian BJ, Pickard JD. Diffusion tensor imaging profiles reveal specific neural tract distortion in normal pressure hydrocephalus. PLoS One. 2017 Aug 17;12(8):e0181624. doi: 10.1371/journal.pone.0181624. eCollection 2017. — View Citation
Marmarou A, Black P, Bergsneider M, Klinge P, Relkin N; International NPH Consultant Group. Guidelines for management of idiopathic normal pressure hydrocephalus: progress to date. Acta Neurochir Suppl. 2005;95:237-40. doi: 10.1007/3-211-32318-x_48. — View Citation
Nakanishi A, Fukunaga I, Hori M, Masutani Y, Takaaki H, Miyajima M, Aoki S. Microstructural changes of the corticospinal tract in idiopathic normal pressure hydrocephalus: a comparison of diffusion tensor and diffusional kurtosis imaging. Neuroradiology. 2013 Aug;55(8):971-976. doi: 10.1007/s00234-013-1201-6. Epub 2013 Jun 2. — View Citation
Siasios I, Kapsalaki EZ, Fountas KN, Fotiadou A, Dorsch A, Vakharia K, Pollina J, Dimopoulos V. The role of diffusion tensor imaging and fractional anisotropy in the evaluation of patients with idiopathic normal pressure hydrocephalus: a literature review. Neurosurg Focus. 2016 Sep;41(3):E12. doi: 10.3171/2016.6.FOCUS16192. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Tract-based spatial statistics and diffusion tensor imaging in patients with idiopathic Normal Pressure Hydrocephalus. | Analysis of data from both techniques and statistical analysis to find which method could be more suitable in patients with idiopathic Normal Pressure Hydrocephalus. | 2 years | |
Primary | White Matter Changes in Idiopathic Normal Pressure Hydrocephalus: A Diffusion Tensor Imaging Study. | Franctional Anisotropi and Apparent Diffusion Coefficient changes before and 3 months after the shunt surgery and correlation with clinical data. All data will be compared with results from the Healthy individual group. | 2 years | |
Secondary | Gastrointestinal and urinary symptoms in idiopathic Normal Pressure Hydrocephalus. | By using questionnaires possible gastrointestinal and urinary symptoms are going to be characterized, check existence and correlate with Diffusion Tensor Imaging data. Statistically control of differences with the Healthy Individual group. | 2 years |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05968976 -
Multicentre RCT of Awake Versus Asleep Tractography Based DBS for ET
|
N/A | |
Recruiting |
NCT05261724 -
Diffusion-tensor Imaging in Brain Tumors Evaluation
|
||
Completed |
NCT04224077 -
Diffusion Tensor Sequences (DTI) for Study of Lumbar Roots by Magnetic Resonance Imaging (MRI)
|
N/A | |
Recruiting |
NCT04507113 -
Diffusion Tensor (DTI) for the Assessement of Therapeutic Evolution of Patients With Acute Lumbar Radiculalgia
|
N/A | |
Recruiting |
NCT05051072 -
Assessment in Patients With Essential Trigeminal Neuralgia of Nerve Involvement by MRI in DTI and Functional Connectivity in "Resting State"
|
N/A |