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Clinical Trial Summary

This is a phase III, randomized, open-label, multicenter trial, conducted in Sweden, Norway, Finland, Denmark, Italy, Australia and New Zealand, in elderly patients with untreated diffuse large B-cell lymphoma. Elderly is defined as either ≥80 years of age, or ≥75 years and frail, according to a simplified Comprehensive Geriatric Assessment. Patients will be randomized 1:1 to either the standard treatment for this population, R-miniCHOP, or an experimental regimen, R-pola-miniCHP, where vincristine is substituted by an immunoconjugate, polatuzumab vedotin. The duration of the screening period is up to 4 weeks. The duration of active treatment is 18 weeks in both arms, and patients will be followed up to 36 months after end of treatment. Start of enrollment is planned in Q1 2020, and the last visit of the last patient included (end of trial) is estimated in Q1 2027.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04332822
Study type Interventional
Source Nordic Lymphoma Group
Contact Mats Jerkeman
Phone 0046704973507
Email mats.jerkeman@med.lu.se
Status Recruiting
Phase Phase 3
Start date August 19, 2020
Completion date December 28, 2028

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