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A Study of Panobinostat in Combination With Everolimus for Children and Young Adults With Gliomas

Glioma Clinical Trial

Official title:
A Phase 2 Study of Panobinostat in Combination With Everolimus for Children and Young Adults With Gliomas Harboring H3.3 or H3.1 K27M Mutation

Clinical Trial Summary

This phase 2 trial will evaluate the activity of Panobinostat in combination with Everolimus for children with gliomas harboring H3.1 or H3.3K27M mutation, including newly diagnosed high-grade glioma or DIPG (diffuse intrinsic pontine glioma) after radiation (stratum A) and recurrent/progressive glioma (grade II-IV, including DIPG) (stratum B).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03632317
Study type Interventional
Source University of Michigan Rogel Cancer Center
Contact
Status Withdrawn
Phase Phase 2
Start date October 2019
Completion date October 2025
View Details
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