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Diffuse Axonal Injury clinical trials

View clinical trials related to Diffuse Axonal Injury.

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NCT ID: NCT06370520 Recruiting - Brain Injuries Clinical Trials

Screening Emotions in Adolescents at the Hospital for mTBI

SEARCH-mTBI
Start date: May 22, 2024
Phase:
Study type: Observational

The goal of this observational study is to develop and validate a clinical tool to predict which adolescents aged 11 to less than 18 years of age with mild traumatic brain injury (mTBI) are at an increased risk for developing significant new or worsening mental health conditions. The main aims the study wish to answer are: - Does the adolescent have new or worsening depression or anxiety defined as a change from their previous medical history using self-reported questionnaires at either one or three months post-injury? - Does the adolescent have unmet mental health care needs, defined as not receiving any mental or behavior health care in patients with new or worsening anxiety or depression as defined by the self reported questionnaires? Participants will be enrolled after being diagnosed in the emergency department (ED) with an mTBI. During the ED visit, the child's parent/caregiver and the adolescent will complete several questionnaires related to mental health which include tools to measure anxiety and depression. Participants will be asked to complete these questionnaires again at 1 month and 3 months post enrollment.

NCT ID: NCT03281759 Recruiting - Clinical trials for Traumatic Brain Injury

Transcranial LED Therapy for Severe Acute Traumatic Brain Injury

LED-TBI
Start date: October 1, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate early and delayed effects of Transcranial LED Therapy (TCLT) and determinate whether this therapy is effective for cognitive rehabilitation of Diffuse Axonal Injury patients after Traumatic Brain Injury.

NCT ID: NCT02852109 Not yet recruiting - Clinical trials for Diffuse Axonal Injury

Diffusion Tensor Imaging to Judge the Prognosis of Patients With Diffuse Axonal Injury

Start date: September 2016
Phase: N/A
Study type: Observational

The investigators will examine 15 patients who was firstly diagnosed as diffuse axonal injury and 15 patients negative for magnetic resonance examination with no trauma with DTI(diffusion tensor imaging). The investigators then determine the FA(fractional anisotropy)value and the ADC(apparent diffusion coefficient) value of relational interesting area(corpus callosum、brainstem、basal ganglia)to analyse the correlation between the FA(fractional anisotropy)value and ADC(apparent diffusion coefficient) value and GCS(Glasgow Coma Scale) and coma time,so that the investigators can quantify the damage degree of patients' white matter fiber.By using fiber tractography the investigators can have the extent of recovery of the patient of DAI(diffuse axonal injury) in real-time detection and give guidance for the clinical decision and the judgement of prognosis).

NCT ID: NCT02757053 Terminated - Brain Injuries Clinical Trials

Screening Brain MRI in High School Football: Does the Guardian Cap Reduce the Risk of Traumatic Brain Injury

Start date: April 2016
Phase: N/A
Study type: Interventional

Screening Brain magnetic resonance imaging (MRI) with Fluid-attenuated Inversion Recovery (FLAIR) and Susceptibility Weighted Imaging (SWI) sequences will be performed pre and post season on high school football players. One set of players will wear the Guardian Cap on their five star rated helmets and the other will wear five star rated helmets only. The investigators will compare outcomes of ImPACT scores and MRI findings between the two groups to see if there is a statistical difference in reduction of injury and to establish what the baseline level of MRI findings related to injury from high school football is as well as what the baseline level of injury is prior to the start of the season.

NCT ID: NCT02742857 Completed - Brain Death Clinical Trials

Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury

Start date: July 2016
Phase: Phase 1
Study type: Interventional

This is the proof of concept study with multi-modality approach (using intra-thecal bioactive peptides, stem cells, laser and transcranial IV laser and Median Nerve stimulation as adjuvants) in cases of brain death due to traumatic brain injury having diffuse axonal injury to document possibility of reversal of brain death (BD).

NCT ID: NCT02167971 Completed - Clinical trials for Traumatic Brain Injury

Brain Stimulation for Traumatic Brain Injury

TMS/DAI
Start date: January 2014
Phase: Phase 2
Study type: Interventional

The purpose of this study is to determine whether repetitive Transcranial Magnetic Stimulation (rTMS) is effective in the cognitive rehabilitation of patients with diffuse axonal injury(DAI) after Traumatic Brain Injury(TBI).