Lenvatinib in Locally Advanced Invasive Thyroid Cancer

Status Recruiting

Clinical Trial Summary

This research is being done to evaluate the safety and efficacy of neoadjuvant lenvatinib on surgical outcomes of patients with invasive extrathyroidal differentiated thyroid cancer (DTC). This research study involves a study drug called lenvatinib

Clinical Trial Description

This is a multicenter, phase II, open-label study examining the effect of neoadjuvant lenvatinib being given to patients with extrathyroidal differentiated thyroid cancer (DTC) prior to surgery to remove cancerous tumors (thyroidectomy). - The research study procedures include screening for eligibility and study treatment including evaluations and follow up visits. - This research study involves a study drug called lenvatinib. - It is anticipated that 30 people will participate in the study. The U.S. Food and Drug Administration (FDA) has not approved lenvatinib for the specific disease of extrathyroidal differentiated thyroid cancer (DTC) but it has been approved for other uses. Phase II clinical trials test the safety and effectiveness of an investigational drug to learn whether the drug works in treating a specific disease. "Investigational" means that the drug is being studied. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04321954
Study type	Interventional
Source	Massachusetts Eye and Ear Infirmary
Contact	Gregory Randolph, MD
Phone	617-573-4115
Email	Gregory_Randolph@MEEI.harvard.edu
Status	Recruiting
Phase	Phase 2
Start date	March 9, 2021
Completion date	March 2025

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