Effects of Dietary Folate and Phytate Zinc Absorption: Zinc Amino Acid Complexes vs. Zinc-chloride

Dietary Zinc Absorption Clinical Trial

Official title:

Comparison of the Effects of Dietary Folate and Phytate on the Absorption of Zinc From Either Zinc-amino Acids (ZnAA) or Zinc-chloride (ZnCl2)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05273710
• Other study ID #: 2020-01-12879
• Status: Completed
• Phase: N/A
• Start date: March 28, 2022
• Est. completion date: November 16, 2022

Study information

• Verified date: December 2022
• Source: University of California, Berkeley
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine the effects of consuming a small breakfast of juice and toast with added phytate or with taking a folic acid supplement on the absorption of a small amount of zinc that is either bound to amino acids or to chloride or picolinate. The results of this study will provide new information on how components of diet (e.g., phytate, and folic acid) affect the absorption of different forms of dietary zinc (e.g., zinc bound to amino acids, zinc chloride, and zinc picolinate).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: November 16, 2022
• Est. primary completion date: November 16, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 19 Years to 50 Years

Eligibility

Inclusion Criteria:

• Apparently healthy men (i.e., have no current health issues requiring medications or a specific diet), 19 to 50 years of age, with a body mass index between 18 and 30 kg/m2, and willing to eat only the foods provided by the study for 17 days

Exclusion Criteria:

• Those reporting current chronic or acute diseases or HIV diagnosis, food allergies, smoking tobacco or marijuana, alcohol abuse, any contraindication to venipuncture such as bleeding disorders or use of blood thinners; use of illicit drugs; regular consumption of medications, micronutrient supplements, or both. Vegetarians, or those unable to eat meat, are also excluded since the foods for the study contain meat.

Related Conditions & MeSH terms

• Dietary Zinc Absorption

Intervention

Other:
• Regular toast and juice
Participants consume a single test meal composed of regular whole wheat toast and apple juice, and zinc absorption is measured.
• High phytate toast and juice
Participants consume a single test meal composed of high phytate whole wheat toast and apple juice, and zinc absorption is measured.
• Regular toast and juice, with folic acid
Participants consume a single test meal composed of regular whole wheat toast and apple juice, with 400 mcg folic acid; and zinc absorption is measured.

Locations

Country	Name	City	State
United States	University of California	Berkeley	California

Sponsors (1)

Lead Sponsor	Collaborator
University of California, Berkeley

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Fractional zinc absorption	Oral zinc tracer to tracee ratio in plasma, as a fraction of intravenous zinc tracer to tracee ratio	48 hours