Dietary Fructose Intolerance Clinical Trial
Official title:
Investigation of Supplemental L-alanine in the Management of Dietary Fructose Intolerance: a Double-blind, Randomized Crossover Study
Data suggest that alanine may facilitate the intestinal absorption of fructose in patients
with DFI and thereby may decrease GI symptoms.
We hypothesize that the ingestion of supplemental L-alanine along with mixed meals or snacks
that contain foods with free fructose or high fructose content will decrease GI symptoms in
subjects with dietary fructose intolerance by facilitating intestinal absorption of fructose.
Aim: To investigate the effects of co- administration of equi-molar doses of L-alanine or
placebo on the occurrence of GI symptoms in subjects with dietary fructose intolerance, in a
randomized, double blind, cross over study.
Methods: We propose to investigate the effects of co-administration of equi-molar doses of
L-alanine or placebo on the occurrence of GI symptoms in 70 subjects with dietary fructose
intolerance, in a randomized, double blind, cross over study.
Data Analysis: The primary outcome measure will be a comparison of baseline breath sample
values and study visit breath sample values. Additionally, we will assess subject-reported
occurence and severity of nine gastrointestinal symptoms during the test on a visual analog
scale (VAS).
Expected Results: We anticipate that dietary fructose intolerance (DFI) symptoms will improve
with ingestion of supplemental L-alanine (along with foods containing free fructose or high
fructose content). We additionally expect treatment of DFI with administration of L-alanine
powder to be more practical than co-ingestion of alanine-rich foods, and more convenient for
patients.
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