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Discovery of Novel Biomarkers of Dietary Exposure in the EPIC Calibration Study

Dietary Exposure Clinical Trial

Official title:
Mining the Urinary and Serum Metabolome for Discovery of Novel Biomarkers of Dietary Exposure in the EPIC Calibration Study

Clinical Trial Summary

This proposal aims at identifying new biomarkers of dietary exposure using metabolomic approaches. This project is based on the European Prospective Investigation on Cancer and Nutrition (EPIC) Calibration Study and more particularly upon a subset of 494 men and women from 4 European countries (Germany, Greece, Italy and France). Urine and blood samples are analyzed by untargeted metabolomics.

Clinical Trial Description

Subjects participating in the study are characterized by the availability of one 24-hr urine sample, blood serum, 24-hr dietary recall (24HDR) and food frequency questionnaire (FFQ) data.

The main objectives of the proposal are:

1. To collect a set of high-quality metabolomic data containing rich information on the food-derived metabolome.

2. To mine this data in different Metabolome-Wide Association Studies in order to identify food-derived metabolites discriminating consumers and non-consumers of various foods, nutrients and dietary patterns.

3. To identify the food-derived metabolites characteristic of the consumption of the different foods/nutrients and dietary patterns. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03683654
Study type Observational
Source International Agency for Research on Cancer
Contact
Status Completed
Phase
Start date April 26, 2012
Completion date February 23, 2013
View Details
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